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5/27/2025 2:51:46 PM | Browse: 13 | Download: 49
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Received |
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2024-12-24 06:45 |
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Peer-Review Started |
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2024-12-25 08:49 |
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To Make the First Decision |
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Return for Revision |
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2025-03-11 08:41 |
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Revised |
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2025-03-14 06:55 |
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Second Decision |
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2025-05-09 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-10 01:11 |
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Articles in Press |
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2025-05-10 01:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-14 08:15 |
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Publish the Manuscript Online |
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2025-05-27 07:04 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Norie Yamada, Hitomi Igarashi, Asako Murayama, Michihiro Suzuki, Kiyomi Yasuda, Masumichi Saito, Masanori Isogawa and Takanobu Kato |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Japan Agency for Medical Research and Development (AMED) |
JP22fk0310503 |
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| Corresponding Author |
Takanobu Kato, Department of Virology II, National Institute of Infectious Diseases, Toyama, 1-23-1, Tokyo 162-8640, Japan. takato@niid.go.jp |
| Key Words |
Tenofovir; Tenofovir alafenamide fumarate; Tenofovir disoproxil fumarate; Resistance; Mutation; Deep sequence |
| Core Tip |
Tenofovir alafenamide fumarate (TAF) is a potent treatment for chronic hepatitis B with low resistance rates. In this study, two TAF-incomplete responders were investigated. In these patients, mutations of rtL269I and combinations of rtT118A/rtL220I were detected in hepatitis B virus (HBV) DNA predominantly as associated with incomplete response to TAF treatment. The deep sequencing of infected HBV DNA and RNA effectively identified responsible mutations, emphasizing its utility in understanding the association between emerged mutations and incomplete responses to TAF and guiding treatment strategies for incomplete responders. |
| Publish Date |
2025-05-27 07:04 |
| Citation |
<p>Yamada N, Igarashi H, Murayama A, Suzuki M, Yasuda K, Saito M, Isogawa M, Kato T. Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment. <i>World J Hepatol</i> 2025; 17(5): 104519</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i5/104519.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i5.104519 |
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