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5/15/2025 12:25:58 PM | Browse: 28 | Download: 54
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Received |
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2025-01-02 09:34 |
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Peer-Review Started |
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2025-01-02 09:34 |
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To Make the First Decision |
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Return for Revision |
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2025-01-18 10:09 |
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Revised |
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2025-01-30 04:46 |
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Second Decision |
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2025-02-27 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-27 07:12 |
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Articles in Press |
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2025-02-27 07:12 |
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Publication Fee Transferred |
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2025-02-07 08:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-27 04:14 |
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Publish the Manuscript Online |
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2025-05-15 10:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Natural killer cell dysfunction is associated with colorectal cancer with severe COVID-19
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Feng Wang, Lu-Zhou Zhang, Tao Liu, Qing-Hong Meng, Jia-Wei Mu and Yu-Liang Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Yu-Liang Wang, MD, PhD, Department of Clinical Laboratory Medicine, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, No. 22 Pingjiang Road, Hexi Distinct, Tianjin 300211, China. wang_yu_l@163.com |
| Key Words |
Colorectal cancer; COVID-19; Natural killer cells; Natural cytotoxicity; Natural killer cytotoxic factor |
| Core Tip |
Severe acute respiratory syndrome coronavirus 2-induced coronavirus disease 2019 (COVID-19) has posed a great challenge to public health worldwide and has also increased susceptibility to colorectal cancer (CRC). As the first line of defense in the host’s innate immune system, natural killer (NK) cells play a key role in rapidly identifying and eliminating cancerous cells, viruses, and infected cells. In this investigation, patients with CRC and severe COVID-19 had lower levels of peripheral NK cells and impaired natural cytotoxicity, either through direct NK cell cytotoxic activity or NK cytotoxic factor release, thereby contributing to the immunopathogenesis of severe COVID-19 rather than immune control, at least to some extent. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Wang JF, Zhang LZ, Liu T, Meng QH, Mu JW, Wang YL. Natural killer cell dysfunction is associated with colorectal cancer with severe COVID-19. <i>World J Gastrointest Oncol</i> 2025; 17(5): 104591</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/104591.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.104591 |
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