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5/26/2025 9:22:13 AM | Browse: 33 | Download: 87
Publication Name World Journal of Radiology
Manuscript ID 104808
Country China
Received
2025-01-03 15:56
Peer-Review Started
2025-01-03 15:56
To Make the First Decision
Return for Revision
2025-03-28 00:47
Revised
2025-04-09 11:37
Second Decision
2025-05-08 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-08 08:53
Articles in Press
2025-05-08 08:53
Publication Fee Transferred
2025-04-14 02:14
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-05-21 00:49
Publish the Manuscript Online
2025-05-26 07:26
ISSN 1949-8470 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type Retrospective Study
Article Title Computed tomography-guided percutaneous biopsy for assessing tumor heterogeneity in neuroendocrine tumor metastases to the liver
Manuscript Source Unsolicited Manuscript
All Author List Lei-Lei Ying, Ke-Ning Li, Wen-Tao Li, Xin-Hong He and Chao Chen
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 82072034
Corresponding Author Chao Chen, PhD, Department of Interventional Radiology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Xuhui District, Shanghai 200032, China. chaochen_cc@fudan.edu.cn
Key Words Image-guided core needle biopsy; Gastroenteropancreatic neuroendocrine tumors; Liver metastases; Survival; Tumor heterogeneity
Core Tip This study demonstrates that percutaneous computed tomography-guided core needle biopsy effectively identifies clinically significant grading heterogeneity in liver metastases from gastroenteropancreatic neuroendocrine tumors. Notably, 40.2% of patients exhibited grade discrepancies between primary and metastatic sites, with upgraded tumors (e.g., G2 to G3) correlating with markedly reduced overall survival. These findings emphasize percutaneous computed tomography-guided core needle biopsy’s pivotal role in optimizing risk stratification, informing personalized therapeutic decisions (e.g., intensified surveillance or targeted therapies), and improving prognostic accuracy for gastroenteropancreatic neuroendocrine tumor patients, while confirming its safety and diagnostic reliability in clinical practice.
Publish Date 2025-05-26 07:26
Citation <p>Ying LL, Li KN, Li WT, He XH, Chen C. Computed tomography-guided percutaneous biopsy for assessing tumor heterogeneity in neuroendocrine tumor metastases to the liver. <i>World J Radiol</i> 2025; 17(5): 104808</p>
URL https://www.wjgnet.com/1949-8470/full/v17/i5/104808.htm
DOI https://dx.doi.org/10.4329/wjr.v17.i5.104808
Full Article (PDF) WJR-17-104808-with-cover.pdf
Manuscript File 104808_Auto_Edited_085853.docx
Answering Reviewers 104808-answering-reviewers.pdf
Audio Core Tip 104808-audio.mp3
Biostatistics Review Certificate 104808-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 104808-conflict-of-interest-statement.pdf
Copyright License Agreement 104808-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 104808-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s) 104808-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 104808-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 104808-non-native-speakers.pdf
Peer-review Report 104808-peer-reviews.pdf
Scientific Misconduct Check 104808-scientific-misconduct-check.png
Scientific Editor Work List 104808-scientific-editor-work-list.pdf
CrossCheck Report 104808-crosscheck-report.pdf