| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Hao Guo, Wen-Jian Zhu, Yi-Fan Hui, Shuo-Qi Zhao, Ting-Ting Zhou, Xue-Meng Wang, Qin-Chang Zhang, Wei Wang, Liu Li, Wei-Xing Shen, Xiao-Yu Wu and Hai-Bo Cheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R and D Program of China |
2022YFC3500200, 2022YFC3500202 and 2022YFC3500204 |
| Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine |
ZYYCXTD-C-202208 |
| NATCM’s Project of High-Level Construction of Key TCM Disciplines |
[2023]85 |
| Qing Lan Project of Jiangsu Higher Education Institutions |
[2023]27 |
| Jiangsu Postgraduate Practice Innovation Plan |
SJCX22_0706 |
| General Project of Universities’ Philosophy and Social Science in Jiangsu Province |
2024SJYB0564 |
| Jiangsu Provincial Leading Talents Program in Traditional Chinese Medicine |
SLJ0314 |
|
| Corresponding Author |
Hai-Bo Cheng, Chief Physician, PhD, Professor, The First Clinical Medical College, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. 2068324936@qq.com |
| Key Words |
Gastrointestinal cancer; Gastric cancer; Colorectal cancer; Traditional Chinese medicine syndrome; Biological basis; Untargeted metabolomics |
| Core Tip |
This study identified differentially expressed metabolites in colorectal cancer and gastric cancer, unraveling the metabolomic characteristics of spleen deficiency and blood stasis toxin (PXYD) syndrome in gastrointestinal cancers. It preliminarily identified 352 common metabolites and 10 metabolic pathways in gastrointestinal cancers, providing a theoretical basis for the "same treatment for different diseases" approach in PXYD syndrome of gastrointestinal cancers. |
| Publish Date |
2025-07-14 12:55 |
| Citation |
<p>Guo TH, Zhu WJ, Hui YF, Zhao SQ, Zhou TT, Wang XM, Zhang QC, Wang W, Li L, Shen WX, Wu XY, Cheng HB. Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study. <i>World J Gastrointest Oncol</i> 2025; 17(7): 104860</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/104860.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.104860 |
