Publication Name	World Journal of Diabetes
Manuscript ID	104879
Country	China

Received	2025-01-05 14:56
Peer-Review Started	2025-01-15 00:42
To Make the First Decision
Return for Revision	2025-03-14 10:25
Revised	2025-03-23 06:06
Second Decision	2025-05-12 11:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-26 09:37
Articles in Press	2025-05-26 09:37
Publication Fee Transferred	2025-03-25 12:02
Edit the Manuscript by Language Editor	2025-06-01 21:10
Typeset the Manuscript	2025-08-04 02:53
Publish the Manuscript Online	2025-08-14 10:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Identification and mechanistic insights of ubiquitin-proteasome system and pyroptosis-related biomarkers in type 2 diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Jing Yuan, Zi-Chen Zhang, Jie Li, Shan-Dong Ye and Wan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270863 and 82470849 Major Project of Anhui Provincial University Research Program 2023AH040400 Joint Fund for Medical Artificial Intelligence MAI2023Q026 The Project of Graduate Education and Teaching Reform Research in Anhui Province 2022jyjxggyj011
Corresponding Author	Wan Zhou, Chief Physician, PhD, Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. zwan@ustc.edu.cn
Key Words	Type 2 diabetes mellitus; Ubiquitin-proteasome system; Pyroptosis; Biomarkers; Intercellular biocommunication; Regulatory networks
Core Tip	This study identifies four ubiquitination and pyroptosis-associated biomarkers (ABCC8, RBP4, RASGRF1, SLC34A2) in type 2 diabetes mellitus (T2DM) through integrated bioinformatics analysis, establishing a potential mechanistic link between ubiquitin-proteasome system dysregulation and pyroptosis in T2DM pathogenesis. These biomarkers are demonstrated significant enriched in oxidative phosphorylation and MAPK signaling pathways, and modulate immune cell infiltration. Our research discovered possible drug candidates and a gene interaction network linked to RNA competition, giving new ideas for improving how we detect and treat type 2 diabetes.
Publish Date	2025-08-14 10:51
Citation	<p>Yuan XJ, Zhang ZC, Li J, Ye SD, Zhou W. Identification and mechanistic insights of ubiquitin-proteasome system and pyroptosis-related biomarkers in type 2 diabetes mellitus. <i>World J Diabetes</i> 2025; 16(8): 104879</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i8/104879.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i8.104879

Full Article (PDF)	WJD-16-104879-with-cover.pdf
The ARRIVE Guidelines	104879-The-ARRIVE-Guidelines.pdf
Manuscript File	104879_Auto_Edited_063825.docx
Answering Reviewers	104879-answering-reviewers.pdf
Audio Core Tip	104879-audio.m4a
Biostatistics Review Certificate	104879-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	104879-conflict-of-interest-statement.pdf
Copyright License Agreement	104879-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	104879-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	104879-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	104879-non-native-speakers.pdf
Supplementary Material	104879-supplementary-material.pdf
Peer-review Report	104879-peer-reviews.pdf
Journal Editor-in-Chief Review Report	104879-journal-editor-in-chief.pdf
Scientific Editor Work List	104879-scientific-editor-work-list.pdf
CrossCheck Report	104879-crosscheck-report.pdf