Publication Name	World Journal of Gastroenterology
Manuscript ID	105157
Country	China

Received	2025-01-14 02:22
Peer-Review Started	2025-01-14 02:22
To Make the First Decision
Return for Revision	2025-03-21 22:59
Revised	2025-04-20 06:04
Second Decision	2025-05-26 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-26 07:29
Articles in Press	2025-05-26 07:29
Publication Fee Transferred	2025-04-23 03:35
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-08 05:32
Publish the Manuscript Online	2025-06-12 03:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Shan-Shan Guo, Yan Zhao, Yan Hu, Xin-Ying Wang, Xu-Zi Zhao, Pei-Yan Zhong, Qin-Rong Luan, Zhe-Cheng Wang and Ji-Hong Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82200658
Corresponding Author	Zhe-Cheng Wang, PhD, Department of Pharmacology, Dalian Medical University, No. 9 West Section, Shunnan Road, Shunkou District, Dalian 116044, Liaoning Province, China. wangzc03@dmu.edu.cn
Key Words	Hepatic ischemia-reperfusion; 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1; Mitophagy; Mitochondrial dynamics; Interacted with insulin-like growing factor 2; mRNA-binding protein 2; mRNA stability
Core Tip	We confirmed the effect of 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) as a new target that controls mitophagy and mitochondrial dynamics in hepatic ischemia-reperfusion. Knockdown of NIPSNAP1 impaired mitophagy and disrupted mitochondrial dynamics, as evidenced by increased mitochondrial fission and reduced fusion. Further studies revealed that interacted with insulin-like growing factor 2 acts as an n6-methyladenosine reader to bind NIPSNAP1 mRNA and enhance its stability, thereby regulating NIPSNAP1 expression. These results suggest that the interacted with insulin-like growing factor 2/NIPSNAP1 axis may be a promising target for hepatic ischemia-reperfusion.
Publish Date	2025-06-12 03:45
Citation	<p>Guo SS, Zhao Y, Hu Y, Wang XY, Zhao XZ, Zhong PY, Luan QR, Wang ZC, Yao JH. N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury. <i>World J Gastroenterol</i> 2025; 31(22): 105157</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i22/105157.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i22.105157

Full Article (PDF)	WJG-31-105157-with-cover.pdf
The ARRIVE Guidelines	105157-The-ARRIVE-Guidelines.pdf
Manuscript File	105157_Auto_Edited_034453.docx
Answering Reviewers	105157-answering-reviewers.pdf
Audio Core Tip	105157-audio.mp3
Biostatistics Review Certificate	105157-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105157-conflict-of-interest-statement.pdf
Copyright License Agreement	105157-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105157-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	105157-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	105157-non-native-speakers.pdf
Supplementary Material	105157-supplementary-material.pdf
Peer-review Report	105157-peer-reviews.pdf
Scientific Misconduct Check	105157-scientific-misconduct-check.png
Scientific Editor Work List	105157-scientific-editor-work-list.pdf
CrossCheck Report	105157-crosscheck-report.pdf