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6/13/2025 2:42:28 PM | Browse: 24 | Download: 54
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Received |
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2025-01-15 08:05 |
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Peer-Review Started |
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2025-01-15 08:06 |
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To Make the First Decision |
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Return for Revision |
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2025-04-11 09:40 |
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Revised |
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2025-04-19 15:06 |
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Second Decision |
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2025-05-13 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-13 07:14 |
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Articles in Press |
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2025-05-13 07:14 |
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Publication Fee Transferred |
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2025-04-22 22:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-21 09:50 |
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Publish the Manuscript Online |
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2025-06-13 13:39 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Endothelial Per-Arnt-Sim domain-containing protein 1 expression is correlated with poor prognosis and promotes invasion and metastasis in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wang Xu, Wang Li and Jia Ru |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jia Ru, Senior Researcher, Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310000, Zhejiang Province, China. 2520089@zju.edu.cn |
| Key Words |
Endothelial Per-Arnt-Sim domain-containing protein 1; Gastric cancer; Survival curve analysis; Immune checkpoint; Bioinformatics analysis |
| Core Tip |
EPAS1 expression is significantly higher in gastric cancer (GC) tissues than in adjacent tissues and is correlated with poor overall survival in patients with GC. High EPAS1 expression is associated with increased infiltration, poor tumor differentiation, and the activation of multiple signaling pathways, including the epithelial-mesenchymal transition, inflammatory response, KRAS, TGF-β, TNF-/NF-kB, and IL6/JAK/STAT3 pathways. EPAS1 also enhances the invasion and metastasis of GC cells. These findings suggest that EPAS1 may serve as an independent prognostic marker and contribute to tumor progression through immune responses and key signaling pathways. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
<p>Xu W, Li W, Ru J. Endothelial Per-Arnt-Sim domain-containing protein 1 expression is correlated with poor prognosis and promotes invasion and metastasis in gastric cancer. <i>World J Gastrointest Oncol</i> 2025; 17(6): 105213</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/105213.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.105213 |
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