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7/10/2025 6:37:06 AM | Browse: 5 | Download: 29
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Received |
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2025-01-16 03:00 |
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Peer-Review Started |
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2025-01-16 03:01 |
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To Make the First Decision |
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Return for Revision |
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2025-03-18 09:09 |
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Revised |
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2025-03-28 09:12 |
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Second Decision |
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2025-05-09 09:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-20 08:17 |
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Articles in Press |
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2025-05-20 08:17 |
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Publication Fee Transferred |
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2025-04-01 08:22 |
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Edit the Manuscript by Language Editor |
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2025-05-22 20:32 |
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Typeset the Manuscript |
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2025-06-23 00:35 |
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Publish the Manuscript Online |
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2025-07-10 03:52 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Efficacy of Pediococcus acidilactici CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Du-Xing Li, Qi-Ming Hu, Chen-Chen Xu, Hong-Yu Yang, Ji-Kang Liu, Yi-Fan Sun, Gang Wang, Jun Wang and Zhen-He Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee |
BJ2023086 |
| Wuxi Taihu Talent Project |
WXTTP 2021 |
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| Corresponding Author |
Jun Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@126.com |
| Key Words |
Anhedonia; Probiotics; Depression; Event-related potentials; Reward processing |
| Core Tip |
Anhedonia, a core symptom of major depressive disorder (MDD), often exhibits poor responsiveness to conventional antidepressants, substantially impairing long-term prognosis. In our randomized controlled trial, adjunctive administration of Pediococcus acidilactici CCFM6432 alongside standard antidepressants demonstrated marked improvements in anhedonia, particularly anticipatory deficits, among MDD patients. Efficacy was quantified through the Temporal Experience of Pleasure Scale and task-specific electroencephalography biomarkers during the Guessing-Door Task, revealing enhanced reward anticipation neural signatures. These findings highlight CCFM6432's clinical potential in addressing anhedonia, with mechanistic implications for gut microbiota-brain axis modulation. |
| Publish Date |
2025-07-10 03:52 |
| Citation |
<p>Li DX, Hu QM, Xu CC, Yang HY, Liu JK, Sun YF, Wang G, Wang J, Zhou ZH. Efficacy of Pediococcus acidilactici CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial. <i>World J Psychiatry</i> 2025; 15(7): 105249</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i7/105249.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i7.105249 |
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