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6/3/2025 9:46:15 AM | Browse: 6 | Download: 17
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Received |
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2025-01-20 11:00 |
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Peer-Review Started |
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2025-01-20 11:00 |
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To Make the First Decision |
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Return for Revision |
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2025-03-30 10:23 |
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Revised |
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2025-04-10 11:26 |
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Second Decision |
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2025-05-13 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-13 08:54 |
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Articles in Press |
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2025-05-13 08:54 |
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Publication Fee Transferred |
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2025-04-14 15:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-28 01:43 |
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Publish the Manuscript Online |
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2025-06-03 08:25 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Comorbidities and systemic steroids drive pneumonia risk in inflammatory bowel disease: Propensity score-matched cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong Eun, Joan Culpepper-Morgan, Abiodun M Akanmode, Myint B Thu, Aprilee A Sta Lucia, Marie S Thearle and Rhonda K Trousdale |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Interdisciplinary Guided Network for Investigation, Translation and Equity for the All of Us Research Program |
OT2 OD031915 |
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| Corresponding Author |
Yong Eun, MD, Department of Medicine, NYC Health + Hospitals/Harlem, 506 Lenox Ave, New York, NY 10037, United States. euny@nychhc.org |
| Key Words |
Inflammatory bowel disease; Bacterial pneumonia; Comorbidity burden; Systemic steroids; Propensity score matching; Risk factor analysis; Immunosuppressive therapy; Pneumococcal vaccination |
| Core Tip |
While increased pneumonia risk in inflammatory bowel disease (IBD) is well-documented, this large propensity-matched study of 5620 participants provides novel insights into its underlying drivers. Using multiple propensity score models, we demonstrate that the heightened pneumonia risk is primarily driven by comorbidities and systemic steroid use, rather than IBD itself. Most notably, patients with a high Charlson Comorbidity Index (≥ 10) showed a 12-fold increased risk, while systemic steroid use doubled the risk. These findings suggest that pneumonia prevention strategies in IBD should prioritize comorbidity management and judicious steroid use, particularly in high-risk patients. |
| Publish Date |
2025-06-03 08:25 |
| Citation |
<p>Eun Y, Culpepper-Morgan J, Akanmode AM, Thu MB, Sta Lucia AA, Thearle MS, Trousdale RK. Comorbidities and systemic steroids drive pneumonia risk in inflammatory bowel disease: Propensity score-matched cohort study. <i>World J Gastrointest Pharmacol Ther</i> 2025; 16(2): 105335</p> |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i2/105335.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i2.105335 |
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