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12/22/2014 11:16:00 AM | Browse: 1128 | Download: 1758
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Received |
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2014-04-06 11:28 |
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Peer-Review Started |
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2014-04-06 18:25 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-05-21 08:48 |
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Revised |
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2014-06-22 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-07-11 16:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-11 17:24 |
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Articles in Press |
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2014-07-11 17:36 |
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Edit the Manuscript by Language Editor |
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2014-07-19 03:59 |
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Typeset the Manuscript |
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2014-12-10 12:24 |
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Publish the Manuscript Online |
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2014-12-20 19:42 |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Cancer-associated fibroblasts in digestive tumors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Huang, A-Man Xu, Sha Liu, Wei Liu and Tuan-Jie Li |
| Funding Agency and Grant Number |
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| Corresponding Author |
Lei Huang, MD, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. huangleizhenting@126.com |
| Key Words |
Cancer-associated fibroblast; Tumor progression; Epithelial-mesenchymal transition; Tumor immunity; Targeted therapy |
| Core Tip |
As a dominant component in tumor stroma, CAFs promote tumorigenesis, and tumor progression by stimulating angiogenesis, malignant cell survival, EMT and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors. CAFs are characterized by expressions of α-SMA, FAP, FSP, vimentin, etc. They are hypothesized to originate from various cells. EMT may also be an important process generating CAFs. There exists a close link between CAFs-induced EMT, chemo-resistance of tumor cells, and tumor stem cells. CAFs significantly induce immunosuppression, and could be a prognostic marker. Targeted therapy toward CAFs has displayed promising anticancer efficacy. |
| Publish Date |
2014-12-20 19:42 |
| Citation |
Huang L, Xu AM, Liu S, Liu W, Li TJ. Cancer-associated fibroblasts in digestive tumors. World J Gastroenterol 2014; 20(47): 17804-17818
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| URL |
http://www.wjgnet.com/1007-9327/full/v20/i47/17804.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i47.17804 |
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