Publication Name	World Journal of Gastroenterology
Manuscript ID	105411
Country	China

Received	2025-01-22 10:39
Peer-Review Started	2025-01-22 10:39
To Make the First Decision
Return for Revision	2025-02-26 01:53
Revised	2025-03-10 16:26
Second Decision	2025-04-16 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-16 10:11
Articles in Press	2025-04-16 10:11
Publication Fee Transferred	2025-03-16 15:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-23 08:08
Publish the Manuscript Online	2025-04-29 09:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Basic Study
Article Title	Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor
Manuscript Source	Unsolicited Manuscript
All Author List	Qing Wang, Chun-Zheng Liu, Bai-Tian Li, Xiu-Qin Yu, Jin-Yuan Zhang, Ze-Tian Wang, Li-Jun Liao and Xiao-Dong Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81971814 Pudong New Area Health Talent Training Program No. 2025PDWSYCBJ-04 Shanghai’s 2023 “Technology Innovation Action Plan” Medical Innovation Research Project No. 23Y11908300
Corresponding Author	Ze-Tian Wang, PhD, Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University School of Medicine, No. 1800 Yuntai Road, Shanghai 200240, China. 18321127738@163.com
Key Words	DL-tryptophan; Necroptosis; Aryl hydrocarbon receptor; Intestinal flora; Intestinal injury; Sepsis
Core Tip	Ozone protected against sepsis-induced intestinal injury through regulation of the gut microbiota and tryptophan metabolism, inhibiting necrotic apoptosis of intestinal cells through activation of the aryl hydrocarbon receptor.
Publish Date	2025-04-29 09:13
Citation	<p>Wang Q, Liu CZ, Li BT, Yu XQ, Zhang JY, Wang ZT, Liao LJ, Liu XD. Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor. <i>World J Gastroenterol</i> 2025; 31(17): 105411</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i17/105411.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i17.105411

Full Article (PDF)	WJG-31-105411-with-cover.pdf
The ARRIVE Guidelines	105411-The-ARRIVE-Guidelines.pdf
Manuscript File	105411_Auto_Edited_083649.docx
Answering Reviewers	105411-answering-reviewers.pdf
Audio Core Tip	105411-audio.mp3
Biostatistics Review Certificate	105411-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105411-conflict-of-interest-statement.pdf
Copyright License Agreement	105411-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105411-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	105411-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	105411-non-native-speakers.pdf
Supplementary Material	105411-supplementary-material.pdf
Peer-review Report	105411-peer-reviews.pdf
Scientific Misconduct Check	105411-scientific-misconduct-check.png
Scientific Editor Work List	105411-scientific-editor-work-list.pdf
CrossCheck Report	105411-crosscheck-report.pdf