Publication Name	World Journal of Critical Care Medicine
Manuscript ID	105428
Country	Pakistan

Received	2025-01-22 08:51
Peer-Review Started	2025-01-22 08:51
To Make the First Decision
Return for Revision	2025-03-05 08:35
Revised	2025-03-15 14:26
Second Decision	2025-04-01 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-01 11:20
Articles in Press	2025-04-01 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-01 06:44
Publish the Manuscript Online	2025-07-18 15:29

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Acute liver failure etiology, clinical manifestation and outcomes in adults: Experience of tertiary care hospital in Karachi
Manuscript Source	Invited Manuscript
All Author List	Nazish Butt, Sabir Ali, Hanisha Khemani and Khalid Mumtaz
Funding Agency and Grant Number
Corresponding Author	Nazish Butt, Associate Professor, Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Rafiqui, Sarwar Shaheed Rd, Karachi Cantonment, Karachi 05444, Pakistan. drnazishbutt@gmail.com
Key Words	Acute liver failure; Hepatitis E virus; Hepatic encephalopathy; Jaundice; Mortality
Core Tip	This study investigates the etiological factors, clinical manifestations, and outcomes of acute liver failure in a tertiary care hospital in Pakistan. Hepatitis E virus was the predominant cause, particularly in pregnant women, with high associated mortality. Jaundice, hepatic encephalopathy, sepsis, and fatigue were significant predictors of poor prognosis. Limited liver transplant facilities contribute to increased mortality, highlighting the urgent need for early referral, risk factor management, and improved supportive care to enhance patient survival.
Publish Date	2025-07-18 15:29
Citation	<p>Butt N, Ali S, Khemani H, Mumtaz K. Acute liver failure etiology, clinical manifestation and outcomes in adults: Experience of tertiary care hospital in Karachi. <i>World J Crit Care Med</i> 2025; 14(3): 105428</p>
URL	https://www.wjgnet.com/2220-3141/full/v14/i3/105428.htm
DOI	https://dx.doi.org/10.5492/wjccm.v14.i3.105428

Full Article (PDF)	WJCCM-14-105428-with-cover.pdf
CONSORT 2010 Statement	105428-CONSORT-2010-statement.pdf
Manuscript File	105428_Auto_Edited_005147.docx
Answering Reviewers	105428-answering-reviewers.pdf
Audio Core Tip	105428-audio.m4a
Biostatistics Review Certificate	105428-biostatistics-statement.pdf
Clinical Trial Registration Statement	105428-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	105428-conflict-of-interest-statement.pdf
Copyright License Agreement	105428-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	105428-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	105428-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	105428-non-native-speakers.pdf
Peer-review Report	105428-peer-reviews.pdf
Scientific Editor Work List	105428-scientific-editor-work-list.pdf
CrossCheck Report	105428-crosscheck-report.pdf