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4/29/2025 9:24:19 AM | Browse: 322 | Download: 742
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Received |
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2025-02-02 05:34 |
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Peer-Review Started |
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2025-02-02 05:34 |
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2025-03-18 20:53 |
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2025-03-18 20:53 |
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2025-03-31 05:40 |
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2025-04-02 05:37 |
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Second Decision by Editor |
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2025-04-21 02:36 |
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Final Decision by Editorial Office Director |
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2025-04-21 06:28 |
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Articles in Press |
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2025-04-21 06:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-24 08:56 |
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Publish the Manuscript Online |
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2025-04-29 09:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Mei Wang, Ze Dai, Dai-Jun Lu, Chao-Qun Bao, Nai-Bin Yang and Yu-Ping Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint TCM Science & Technology Projects of National Demonstration Zones for Comprehensive TCM Reform |
GZY-KJS-ZJ-2025-044 |
| Ningbo Top Medical and Health Research Program |
2023020612 |
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| Corresponding Author |
Yu-Ping Zhou, PhD, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Ningbo University, No. 247 Renmin Road, Jiangbei District, Ningbo 315020, Zhejiang Province, China. fyzhouyuping@nbu.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Bicuculline; Nuclear factor-kappa B; Lipid metabolism; Lipid accumulation; Hepatic steatosis |
| Core Tip |
This study identifies bicuculline (BIC) as a novel agent for treating metabolic dysfunction-associated steatotic liver disease (MASLD), demonstrating for the first time the dual efficacy of BIC in reducing hepatic lipid accumulation and inflammation via nuclear factor-kappa B (NF-κB) pathway inhibition. Experiments involving zebrafish, mouse, and cellular (HepG2 and AML12) models confirmed that, mechanistically, BIC disrupts the NF-κB signaling pathway, which is a central hub that links metabolic dysfunction and inflammation in MASLD. Transcriptomic insights confirm pathway-specific targeting, distinguishing BIC from broad-spectrum therapies. These findings not only reveal a new axis that can be targeted in the treatment of MASLD but also position BIC as a precision therapeutic candidate with translational promise. The multimodel validation highlights the robustness of BIC, advancing this agent toward clinical exploration. |
| Publish Date |
2025-04-29 09:13 |
| Citation |
Wang XM, Dai Z, Lu DJ, Bao CQ, Yang NB, Zhou YP. Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation. World J Gastroenterol 2025; 31(17): 105438 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i17/105438.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i17.105438 |
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