| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kang-Ning Li, Shi-Xiong Tang, You-Fu Tao, Hai-Ruo He, Mo-Han Ma, Qian-Qian Zhang, Mei Huang, Wen-Tao Chen, Hui Liang, Ao-Qian Deng, Si-Rui Gao, Fan-Yu Meng, Yi-Lin Peng, Yu-Meng Ju, Wen-Wen Ou, Su Shu and Yan Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2021ZD0202000 |
| National Natural Science Foundation of China |
82101612 and 82471570 |
| Natural Science Foundation of Hunan Province |
2022JJ40692 |
| Science and Technology Innovation Program of Hunan Province |
2021RC2040 |
| Science and Technology Innovation Program of Hunan Province |
2024RC3056 |
|
| Corresponding Author |
Su Shu, PhD, Department of Psychiatry, Psychiatrist, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Furong District, Changsha 410011, Hunan Province, China. shusujy@163.com |
| Key Words |
Neural mechanism; Network topology; Functional connectivity; Rumination; Major depressive episode |
| Core Tip |
Rumination is a key risk factor for relapse in major depressive episode (MDE) patients, yet its neural mechanisms in remitted MDEs remain unclear. Using a rumination induction neuroimaging task, we analyzed brain network alterations during rumination. The alterations in functional connectivity between the rumination and distraction states occurred mainly in the frontoparietal, default mode, and cerebellar networks. Topology analysis revealed that the whole-brain network was more functionally integrated and less segregated during rumination. These altered network topological characteristics were associated with individual rumination levels, providing insights into the neural basis of rumination in remitted MDE patients. |
| Publish Date |
2025-05-29 09:14 |
| Citation |
<p>Li KN, Tang SX, Tao YF, He HR, Ma MH, Zhang QQ, Huang M, Chen WT, Liang H, Deng AQ, Gao SR, Meng FY, Peng YL, Ju YM, Ou WW, Shu S, Zhang Y. Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses. <i>World J Psychiatry</i> 2025; 15(6): 105555</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i6/105555.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i6.105555 |
