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5/21/2025 8:17:46 AM | Browse: 20 | Download: 18
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2025-01-30 14:56 |
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2025-01-30 14:56 |
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2025-03-11 00:25 |
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2025-03-15 01:59 |
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2025-04-01 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-01 05:28 |
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Articles in Press |
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2025-04-01 05:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-14 05:58 |
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Publish the Manuscript Online |
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2025-05-21 05:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Leandro Sierra, Mohamad-Noor Abu-Hammour, Arjun Chatterjee and C Roberto Simons-Linares |
| Funding Agency and Grant Number |
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| Corresponding Author |
C Roberto Simons-Linares, MD, Senior Researcher, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, United States. simonsc@ccf.org |
| Key Words |
Obesity paradox; Hepatocellular carcinoma; Immunotherapy; Anti-programmed death-1 therapy; Leptin; Anti-vascular endothelial growth factor therapy |
| Core Tip |
The “obesity paradox” in hepatocellular carcinoma suggests better outcomes in patients with obesity undergoing immunotherapy, potentially due to leptin-driven immune modulation and enhanced nutritional reserves. While promising, these findings have only been demonstrated with lenvatinib and camrelizumab, and have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab. Although intriguing, this phenomenon remains limited by the scope of current studies. |
| Publish Date |
2025-05-21 05:53 |
| Citation |
<p>Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. <i>World J Gastroenterol</i> 2025; 31(19): 105617</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i19/105617.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i19.105617 |
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