Publication Name	World Journal of Transplantation
Manuscript ID	105621
Country	Croatia

Received	2025-02-02 04:44
Peer-Review Started	2025-02-02 04:44
To Make the First Decision
Return for Revision	2025-03-14 11:32
Revised	2025-03-25 18:48
Second Decision	2025-04-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-15 11:02
Articles in Press	2025-04-15 11:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 12:46
Publish the Manuscript Online	2025-11-19 05:57

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Editorial
Article Title	YKL-40: Revolutionizing cardiac risk prediction and therapy in liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Ileana Lulic, Dinka Lulic, Ivan Durekovic, Jadranka Pavicic Saric, Iva Bacak Kocman, Zrinka Sarec and Dunja Rogic
Funding Agency and Grant Number
Corresponding Author	Ileana Lulic, MD, Postdoctoral Fellow, Department of Anesthesiology, Intensive Care and Pain Medicine, Clinical Hospital Merkur, Zajceva 19, Zagreb 10000, Croatia. ileanalulic@gmail.com
Key Words	Liver transplantation; Translational research; Biomarkers; YKL-40; Cardiovascular risk stratification; Survival
Core Tip	YKL-40 is a biomarker of cardiovascular dysfunction in liver transplant (LT) recipients, reflecting underlying inflammation, endothelial activation, and fibrosis. Its integration into cardiovascular risk models may improve perioperative stratification, complement existing screening tools, and support early identification of high-risk patients. Mechanistic insights and artificial intelligence–driven analytics support its future role in targeted risk reduction, while clinical adoption will require prospective validation, actionable thresholds, and structured incorporation into multimodal assessment frameworks to improve outcomes in LT recipients.
Publish Date	2025-11-19 05:57
Citation	<p>Lulic I, Lulic D, Durekovic I, Pavicic Saric J, Bacak Kocman I, Sarec Z, Rogic D. YKL-40: Revolutionizing cardiac risk prediction and therapy in liver transplantation. <i>World J Transplant</i> 2025; 15(4): 105621</p>
URL	https://www.wjgnet.com/2220-3230/full/v15/i4/105621.htm
DOI	https://dx.doi.org/10.5500/wjt.v15.i4.105621

Full Article (PDF)	WJT-15-105621-with-cover.pdf
Manuscript File	105621_Auto_Edited_040218.docx
Answering Reviewers	105621-answering-reviewers.pdf
Audio Core Tip	105621-audio.m4a
Conflict-of-Interest Disclosure Form	105621-conflict-of-interest-statement.pdf
Copyright License Agreement	105621-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	105621-non-native-speakers.pdf
Peer-review Report	105621-peer-reviews.pdf
Scientific Misconduct Check	105621-scientific-misconduct-check.png
Scientific Editor Work List	105621-scientific-editor-work-list.pdf
CrossCheck Report	105621-crosscheck-report.pdf