Publication Name	World Journal of Methodology
Manuscript ID	105775
Country	China

Received	2025-02-07 04:33
Peer-Review Started	2025-02-11 00:39
To Make the First Decision
Return for Revision	2025-03-05 10:21
Revised	2025-03-12 12:24
Second Decision	2025-03-19 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-21 02:18
Articles in Press	2025-03-21 02:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 12:52
Publish the Manuscript Online	2025-08-04 12:11

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Respiratory System
Manuscript Type	Basic Study
Article Title	Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment
Manuscript Source	Invited Manuscript
All Author List	Dao-Jian Xu, Qiang Zhong, Guo-Tao Wang and Xiang Lu
Funding Agency and Grant Number	Funding Agency Grant Number The Zhejiang Provincial Health Commission No. 2022KY1391
Corresponding Author	Xiang Lu, PhD, Department of Emergency, Taizhou Municipal Hospital, No. 381 Zhongshan East Road, Jiaojiang District, Taizhou 318099, Zhejiang Province, China. cqlu1978@126.com
Key Words	COVID-19; Drug discovery; Hypoxemia; Magnesium sulfate; Nikethamide; Seizures
Core Tip	Nikethamide is a respiratory stimulant used for the treatment of coronavirus disease 2019 (COVID-19); however, its use carries the risk of seizure induction. This study demonstrates that magnesium sulfate (MgSO4) can effectively prevent and mitigate nikethamide-induced seizures in a dose-dependent manner. The results indicate that MgSO4 prolongs seizure latency, reduces seizure severity, extends seizure duration, and decreases mortality in the experimental model. These findings provide important insights into the potential clinical application of MgSO4 for managing nikethamide-associated seizure complications in COVID-19 patients.
Publish Date	2025-08-04 12:11
Citation	<p>Xu DJ, Zhong Q, Wang GT, Lu X. Preventive and therapeutic effects of magnesium sulfate on nikethamide-induced seizures: Implications for COVID-19 treatment. <i>World J Methodol</i> 2025; 15(4): 105775</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i4/105775.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i4.105775

Full Article (PDF)	WJM-15-105775-with-cover.pdf
The ARRIVE Guidelines	105775-The-ARRIVE-Guidelines.pdf
Manuscript File	105775_Auto_Edited_084046.docx
Answering Reviewers	105775-answering-reviewers.pdf
Audio Core Tip	105775-audio.mp3
Biostatistics Review Certificate	105775-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	105775-conflict-of-interest-statement.pdf
Copyright License Agreement	105775-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	105775-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	105775-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	105775-non-native-speakers.pdf
Peer-review Report	105775-peer-reviews.pdf
Scientific Misconduct Check	105775-scientific-misconduct-check.png
Scientific Editor Work List	105775-scientific-editor-work-list.pdf
CrossCheck Report	105775-crosscheck-report.pdf