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9/24/2025 6:48:18 AM | Browse: 34 | Download: 35
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Received |
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2025-02-10 08:18 |
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Peer-Review Started |
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2025-02-11 08:25 |
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To Make the First Decision |
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Return for Revision |
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2025-03-25 07:31 |
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Revised |
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2025-04-07 12:37 |
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Second Decision |
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2025-07-28 05:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-04 09:01 |
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Articles in Press |
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2025-08-04 09:01 |
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Publication Fee Transferred |
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2025-04-09 02:58 |
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Edit the Manuscript by Language Editor |
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2025-08-12 20:08 |
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Typeset the Manuscript |
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2025-09-06 15:04 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Quercetin pre-treated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease via IL-10/JAK2/STAT3 signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Yue Shi, Lian Liu and Fu-Yuan Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Research Project of Hubei Province |
2021CFB210 |
| Central Guiding Local Science and Technology Development Fund Project (Science and Technology Department of Xizang Autonomous Region) |
XZ202401YD0002C |
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| Corresponding Author |
Fu-Yuan Yang, PhD, Department of Anaesthesiology, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Shashi District, Jingzhou 434020, Hubei Province, China. ivansblue@sina.com |
| Key Words |
Quercetin; Human umbilical cord-derived mesenchymal stem cells; Inflammatory bowel disease; Interleukin-10; Janus kinase/signal transducer and activator of transcription/suppressor of cytokine signaling signal |
| Core Tip |
Quercetin (QUR) pretreatment enhanced the viability of human umbilical cord-derived mesenchymal stem cells (hUCMSCs), which may improve their immune regulatory ability. Intraperitoneal injection of QUR-hUCMSCs effectively alleviated inflammation in 2,4,6-trinitrobenzenesulfonic acid mice, and the therapeutic effect was superior to untreated hUCMSCs. QUR-hUCMSCs treatment significantly enhanced interleukin-10 expression in 2,4,6-trinitrobenzenesulfonic acid mice. QUR-hUCMSCs inhibit inflammatory bowel disease inflammation by regulating the interleukin-10/Janus kinase/signal transducer and activator of transcription signaling pathway. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Shi MY, Liu L, Yang FY. Quercetin pre-treated umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease via IL-10/JAK2/STAT3 signaling. <i>World J Stem Cells</i> 2025; 17(9): 105896</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/105896.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.105896 |
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