| ISSN |
1948-9366 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Huangqi decoction ameliorated intestinal barrier dysfunction via regulating NF-κB signaling pathway in slow transit constipation model mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua-Xian Chen, Guo-Zhong Xiao, Chao-Xin Yang, Yi-Hui Zheng, Ming-Yuan Lei, Hao Xu, Dong-Lin Ren, Liang Huang, Qiu-Lan He and Hong-Cheng Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangdong Province for Distinguished Young Scholars |
2022B1515020003 |
| National Natural Science Foundation of China |
82174369, 82405397, 82374442, and 81973847 |
| National Key Clinical Discipline |
|
| the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases |
2020B1111170004 |
| Postdoctoral Fellowship Program of CPSF |
GZC20233247 |
|
| Corresponding Author |
Hong-Cheng Lin, Department of General Surgery (Department of Coloproctology), The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Yuancun Erheng Road, Guangzhou 510655, Guangdong Province, China. lhcheng@mail.sysu.edu.cn |
| Key Words |
Protective effects; Intestinal barrier dysfunction; Multi-omics; Huangqi decoction; Slow transit constipation |
| Core Tip |
Huangqi decoction (HQD) alleviates slow transit constipation (STC) by suppressing the nuclear factor κB pathway and restoring intestinal barrier integrity. Employing single-cell RNA sequencing and spatial transcriptomics sequencing, we demonstrated HQD reverses STC-induced goblet cell depletion, enhances mucin 2 secretion, and reactivates Wnt/β-catenin-mediated intestinal stem cell proliferation. HQD downregulated nuclear factor κB signaling across cell types, notably inhibiting hyperactivation in goblet cells while promoting Enterocyte_C1 differentiation. These findings reveal HQD’s dual mechanism: Repairing mucosal barrier dysfunction via epithelial regulation and modulating enterocyte states, positioning it as a therapeutic strategy targeting mucosal repair in STC. |
| Publish Date |
2025-05-23 08:06 |
| Citation |
<p>Chen HX, Xiao GZ, Yang CX, Zheng YH, Lei MY, Xu H, Ren DL, Huang L, He QL, Lin HC. Huangqi decoction ameliorated intestinal barrier dysfunction via regulating NF-κB signaling pathway in slow transit constipation model mice. <i>World J Gastrointest Surg</i> 2025; 17(5): 106000</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i5/106000.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i5.106000 |
