| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xuan-Li Su, Fu-Rong Xu, Jian Yang, San-Qiang Niu, Hao-Jie Shi, Yu-Fan He, Zhen-Hao Li, Pankaj Bagari, Xiang-Wei Wu, Xin-Yu Peng, Hong-Wei Zhang and Mei-Yan Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of Xinjiang Production and Construction Corps |
2022ZD090 |
| Project of Xinjiang Production and Construction Corps - Young Science and Technology Innovation Talents |
2023CB008-31 |
| The First Affiliated Hospital of Shihezi University Medical College, Doctoral Fund Project |
BS202207 |
| Talent Development Fund-Tianshan Talents |
CZ001219 |
| 2024 National Health Commission Central Asian High-Incidence Prevention and Control Key Laboratory |
KF202405 |
|
| Corresponding Author |
Jian Yang, Professor, Professor Emerita, Department of Emergency, The First Affiliated Hospital of Shihezi University, North Fourth Road, Shihezi 832000, Xinjiang Uygur Autonomous Region, China. 125210525@qq.com |
| Key Words |
Nanoparticles; Bone marrow mesenchymal stem cells; Calcification; Apoptosis; Transforming growth factor-β/Smad signaling pathway; Hydroxyapatite |
| Core Tip |
This study revealed calcifying nanoparticles (CNPs) induce cell apoptosis and calcification on bone marrow mesenchymal stem cells. Through in vitro experiments, we found that CNPs inhibit cell proliferation in a concentration dependent manner and significantly enhance the expression of pro-apoptotic and pro-calcification markers. In addition, the transforming growth factor-β/Smad signaling pathway plays a crucial role in this process. These findings provide a new perspective for understanding the potential applications of CNPs in tissue repair and regenerative medicine. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Su XL, Xu FR, Yang J, Niu SQ, Shi HJ, He YF, Li ZH, Bagari P, Wu XW, Peng XY, Zhang HW, Wang MY. Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway. World J Stem Cells 2025; 17(12): 106128 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/106128.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.106128 |
