Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	106219
Country	Canada

Received	2025-02-20 06:57
Peer-Review Started	2025-02-20 06:57
To Make the First Decision
Return for Revision	2025-04-08 03:48
Revised	2025-04-21 22:40
Second Decision	2025-06-05 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-07 02:38
Articles in Press	2025-06-07 02:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-20 09:11
Publish the Manuscript Online	2025-10-31 15:02

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Gestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy
Manuscript Source	Invited Manuscript
All Author List	Nourane Helali, Hugo Gagnon and Fernando Álvarez
Funding Agency and Grant Number
Corresponding Author	Fernando Álvarez, MD, Professor, Department of Gastroenterology, Hepatology and Nutrition, CHU Sainte-Justine, 3175 Chem de la Côte-Sainte-Catherine, Montreal H3T1C5, Quebec, Canada. fernando.alvarez@umontreal.ca
Key Words	Gestational allo-immune liver disease; Neonatal liver failure; Neonatal hemochromatosis; Intravenous immunoglobulin therapy; Liver transplantation
Core Tip	Gestational alloimmune liver disease is a rare neonatal hepatic condition with clinical manifestations ranging from benign presentations to fulminant liver failure. Curative treatments include intravenous immunoglobulin (IVIG) and double-volume plasma exchange; liver transplantation may be necessary in severe cases. The recurrence rate in subsequent pregnancies is as high as 90%, but it can be effectively prevented with antenatal IVIG administration. In this review, we summarize the latest available literature to raise awareness among pediatricians and pediatric hepatologists, ensuring early recognition and appropriate management of this condition.
Publish Date	2025-10-31 15:02
Citation	<p>Helali N, Gagnon H, Álvarez F. Gestational alloimmune liver disease reconsidered: Advocating for a new nomenclature and enhanced diagnosis accuracy. <i>World J Clin Pediatr</i> 2025; 14(4): 106219</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i4/106219.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i4.106219

Full Article (PDF)	WJCP-14-106219-with-cover.pdf
Manuscript File	106219_Auto_Edited_061405.docx
Answering Reviewers	106219-answering-reviewers.pdf
Audio Core Tip	106219-audio.m4a
Conflict-of-Interest Disclosure Form	106219-conflict-of-interest-statement.pdf
Copyright License Agreement	106219-copyright-assignment.pdf
Peer-review Report	106219-peer-reviews.pdf
Scientific Misconduct Check	106219-scientific-misconduct-check.png
Scientific Editor Work List	106219-scientific-editor-work-list.pdf
CrossCheck Report	106219-crosscheck-report.pdf