Publication Name	World Journal of Clinical Oncology
Manuscript ID	106229
Country	China

Received	2025-02-20 06:31
Peer-Review Started	2025-02-20 06:31
To Make the First Decision
Return for Revision	2025-04-16 00:51
Revised	2025-04-22 21:46
Second Decision	2025-05-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-18 13:26
Articles in Press	2025-05-18 13:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-09 08:14
Publish the Manuscript Online	2025-06-20 08:05

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Depression in gastric cancer patients: Integrated therapeutic strategies and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Pei-Yuan Yu, Feng Liu, Yan Jiao, Yue-Chen Zhao and Ya-Hui Liu
Funding Agency and Grant Number
Corresponding Author	Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Key Words	Gastric cancer; Depression comorbidity; Psychosocial interventions; Integrated therapeutic strategies; Biomarker-driven therapies
Core Tip	Depression is a common and impactful comorbidity in gastric cancer patients, significantly affecting treatment adherence, quality of life, and survival. A bidirectional relationship exists between depression and gastric cancer, where psychological distress exacerbates cancer progression, and cancer-related burdens worsen depressive symptoms. Effective management requires a holistic, integrated approach, combining pharmacological treatments, psychotherapeutic interventions, and complementary therapies. Multidisciplinary care, incorporating emotional support, pain management, and nutritional strategies, is crucial for improving both psychological and physical outcomes. Future research should focus on personalized therapies targeting both stress-related pathways and individualized psychosocial support to optimize patient well-being and treatment efficacy.
Publish Date	2025-06-20 08:05
Citation	<p>Yu PY, Liu F, Jiao Y, Zhao YC, Liu YH. Depression in gastric cancer patients: Integrated therapeutic strategies and clinical implications. <i>World J Clin Oncol</i> 2025; 16(6): 106229</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i6/106229.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i6.106229

Full Article (PDF)	WJCO-16-106229-with-cover.pdf
Manuscript File	106229_Auto_Edited_064101.docx
Answering Reviewers	106229-answering-reviewers.pdf
Audio Core Tip	106229-audio.mp3
Conflict-of-Interest Disclosure Form	106229-conflict-of-interest-statement.pdf
Copyright License Agreement	106229-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	106229-non-native-speakers.pdf
Peer-review Report	106229-peer-reviews.pdf
Scientific Misconduct Check	106229-scientific-misconduct-check.png
Scientific Editor Work List	106229-scientific-editor-work-list.pdf
CrossCheck Report	106229-crosscheck-report.pdf