Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106244
Country	China

Received	2025-02-20 04:36
Peer-Review Started	2025-02-20 04:37
To Make the First Decision
Return for Revision	2025-02-28 06:15
Revised	2025-03-02 05:28
Second Decision	2025-03-11 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-11 07:57
Articles in Press	2025-03-11 07:57
Publication Fee Transferred	2025-03-03 01:15
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-30 16:00
Publish the Manuscript Online	2025-05-15 10:28

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Nomogram-based prognostic stratification for resectable gastric signet-ring cell carcinoma and adenocarcinoma: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Tao Hu, Peng Wang, Yu-Juan Jiang, Hai-Kuo Wang, Xin-Xin Shao and Yan-Tao Tian
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82473285 Beijing Hope Run Special Fund of Cancer Foundation of China No. LC2002B02
Corresponding Author	Yan-Tao Tian, PhD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tyt67@163.com
Key Words	Gastric cancer; Adenocarcinoma; Signet-ring cell carcinoma; Nomogram; Prognostic model; Retrospective cohort study
Core Tip	This large-scale, retrospective cohort study compared prognostic outcomes of gastric adenocarcinoma and gastric signet-ring cell carcinoma (GSRCC) and revealed heterogeneous survival risks. While no overall survival difference was observed, GSRCC demonstrated significantly worse prognosis in age ≥ 60 years, size ≥ 4 cm, and poor differentiation. A new nomogram incorporating seven clinicopathological variables demonstrated greater accuracy than traditional tumor node metastasis staging in predicting 1-, 3-, and 5-year overall survival (P < 0.001). Key innovations include the application of least absolute shrinkage and selection operator regression to address multicollinearity and propensity score matching to minimize baseline bias. Integration of the model into clinical workflows could enable real-time risk stratification and guide personalized therapy for resectable gastric cancer.
Publish Date	2025-05-15 10:28
Citation	<p>Hu HT, Wang P, Jiang YJ, Wang HK, Shao XX, Tian YT. Nomogram-based prognostic stratification for resectable gastric signet-ring cell carcinoma and adenocarcinoma: A retrospective cohort study. <i>World J Gastrointest Oncol</i> 2025; 17(5): 106244</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i5/106244.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i5.106244

Full Article (PDF)	WJGO-17-106244-with-cover.pdf
STROBE Statement	106244-STROBE-statement.pdf
Manuscript File	106244_Auto_Edited_011112.docx
Answering Reviewers	106244-answering-reviewers.pdf
Audio Core Tip	106244-audio.wav
Biostatistics Review Certificate	106244-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106244-conflict-of-interest-statement.pdf
Copyright License Agreement	106244-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106244-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	106244-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	106244-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106244-non-native-speakers.pdf
Peer-review Report	106244-peer-reviews.pdf
Scientific Misconduct Check	106244-scientific-misconduct-check.png
Scientific Editor Work List	106244-scientific-editor-work-list.pdf
CrossCheck Report	106244-crosscheck-report.png
CrossCheck Report	106244-crosscheck-report.pdf