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10/14/2025 8:18:13 AM | Browse: 111 | Download: 157
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Received |
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2025-02-26 10:47 |
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Peer-Review Started |
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2025-02-26 10:48 |
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To Make the First Decision |
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Return for Revision |
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2025-04-03 08:49 |
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Revised |
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2025-04-29 11:10 |
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Second Decision |
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2025-06-16 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-16 09:20 |
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Articles in Press |
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2025-06-16 09:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-06-22 20:59 |
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Typeset the Manuscript |
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2025-10-08 09:13 |
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Publish the Manuscript Online |
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2025-10-14 07:42 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
MEX3A promotes hepatocellular carcinoma cell proliferation and migration via the Wnt/β-catenin and EMT pathways
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fan-Kai Xiao, Ping Li, Xin-Min Li and Yin Mi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Youth Foundation of He’nan Scientific Committee |
202300410416 |
| Henan Province Medical Science, Technology Breakthrough Plan Project |
LHGJ20190033 |
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| Corresponding Author |
Fan-Kai Xiao, Associate Professor, MD, PhD, oncology, first affiliated hospital of zhengzhou university, No,1 jianshe Rd, Zhengzhou China, Zhengzhou 450052, Henan Province, China. xfkw@hotmail.com |
| Key Words |
MEX3A; Hepatocellular carcinoma; Epithelial-mesenchymal transition; Biomarker; Proliferation; Migration |
| Core Tip |
This letter analysis of The Cancer Genome Atlas data revealed that MEX3A mRNA expression is significantly higher in hepatocellular carcinoma (HCC) tissues compared to adjacent non-tumor tissues. High MEX3A expression was associated with worse overall survival in HCC patients. Knockdown of MEX3A in HCC cell lines (HepG2 and MHCC-97H) significantly inhibited cell proliferation and colony formation. MEX3A silencing induced cell cycle arrest at the G1 phase, accompanied by decreased expression of cyclin D1 and increased expression of p21, a cell cycle inhibitor. MEX3A knockdown reduced the nuclear translocation of β-catenin (P < 0.05), a key component of the Wnt signaling pathway, and downregulated downstream targets such as c-Myc and cyclin D1. The development of treatments targeting genes with oncogenic alterations and related signaling pathways, based on advances in understanding of molecular cancer biology, was a major step in cancer treatment evolution. |
| Publish Date |
2025-10-14 07:42 |
| Citation |
<p>Xiao FK, Li P, Li XM, Mi Y. MEX3A promotes hepatocellular carcinoma cell proliferation and migration via the Wnt/β-catenin and EMT pathways. <i>World J Gastrointest Oncol</i> 2025; 17(10): 106410</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i10/106410.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i10.106410 |
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