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6/12/2025 6:41:54 AM | Browse: 22 | Download: 20
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Received |
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2025-03-03 01:38 |
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Peer-Review Started |
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2025-03-03 01:38 |
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To Make the First Decision |
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Return for Revision |
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2025-04-04 01:28 |
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Revised |
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2025-04-09 20:31 |
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Second Decision |
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2025-05-26 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-26 06:27 |
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Articles in Press |
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2025-05-26 06:27 |
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Publication Fee Transferred |
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2025-04-28 17:48 |
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Edit the Manuscript by Language Editor |
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2025-06-01 20:56 |
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Typeset the Manuscript |
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2025-06-08 05:40 |
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Publish the Manuscript Online |
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2025-06-12 03:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Xi Wang, Peng Ge and Hai-Long Chen |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hai-Long Chen, PhD, Professor, Department of General Surgery, Pancreatic-Biliary Center, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. chenhailong@dmu.edu.cn |
| Key Words |
Severe acute pancreatitis; Hypertriglyceridemia; Saturated fatty acid; Unsaturated fatty acid; M1 macrophage polarization |
| Core Tip |
The editor reviews the article about the possible reasons of hyperlipidemic pancreatitis and highlighted that intake of more saturated fatty acids (SFAs) initially elevates more pancreatic lipase activity, accelerating lipolysis and fat necrosis, which in turn increases free fatty acids levels and opens the gate for inflammation in severe acute pancreatitis. This process accelerates immune response of M1 macrophage polarization and subsequent acinar damage. Over time, unsaturated fatty acids (UFAs) worsen the damage to acinar cells and impair β-cell function in the pancreas, leading to diabetes. This cumulative effect is a consistent and damaging process. Therefore, the ratio of UFAs to SFAs is crucial in the pathogenesis of severe acute pancreatitis, and the progression is complex. It is essential to clearly distinguish the main roles of SFAs and UFAs in the development of severe acute pancreatitis. |
| Publish Date |
2025-06-12 03:45 |
| Citation |
<p>Wang YX, Ge P, Chen HL. Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review. <i>World J Gastroenterol</i> 2025; 31(22): 106575</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i22/106575.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i22.106575 |
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