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7/24/2025 9:31:54 AM | Browse: 10 | Download: 32
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Received |
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2025-03-07 08:00 |
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Peer-Review Started |
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2025-03-11 08:20 |
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To Make the First Decision |
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Return for Revision |
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2025-04-07 12:24 |
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Revised |
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2025-04-15 14:41 |
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Second Decision |
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2025-06-18 05:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-25 07:44 |
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Articles in Press |
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2025-06-25 07:44 |
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Publication Fee Transferred |
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2025-04-19 01:04 |
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Edit the Manuscript by Language Editor |
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2025-06-28 20:12 |
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Typeset the Manuscript |
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2025-07-16 06:25 |
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Publish the Manuscript Online |
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2025-07-24 09:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Observational Study |
| Article Title |
Recombinant human thrombopoietin safety and efficacy in pediatric allogeneic hematopoietic stem cell transplantation: A cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Guo Li, Ru-Min Wang, Wei Chen, Tong Yao, Fen Chen, Yan-Fang Xu and Tao Lang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Tao Lang, Chief Physician, MD, Department of Hematology, The People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. langt2024@163.com |
| Key Words |
Recombinant human thrombopoietin; Pediatric hematologic disorders; Allogeneic hematopoietic stem cell transplantation; Platelet engraftment; Graft-versus-host disease |
| Core Tip |
This study evaluates the safety and efficacy of recombinant human thrombopoietin (rhTPO) in pediatric patients (0-17 years) undergoing allogeneic hematopoietic stem cell transplantation. Results show that rhTPO is well-tolerated and improves platelet recovery, with shorter platelet engraftment times in children (0-9 years) compared to adolescents (10-17 years). The incidence of acute graft-versus-host disease was higher in children but less severe. No severe adverse events related to rhTPO were observed, supporting its safety and utility in pediatric allogeneic hematopoietic stem cell transplantation. This study provides foundational insights for further research in larger pediatric cohorts. |
| Publish Date |
2025-07-24 09:11 |
| Citation |
<p>Li XG, Wang RM, Chen W, Yao T, Chen F, Xu YF, Lang T. Recombinant human thrombopoietin safety and efficacy in pediatric allogeneic hematopoietic stem cell transplantation: A cohort study. <i>World J Stem Cells</i> 2025; 17(7): 106579</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i7/106579.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i7.106579 |
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