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8/14/2025 12:06:09 PM | Browse: 342 | Download: 612
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Received |
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2025-03-12 05:16 |
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Peer-Review Started |
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2025-03-20 09:07 |
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First Decision by Editorial Office Director |
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2025-04-17 03:49 |
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Return for Revision |
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2025-04-17 03:49 |
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Revised |
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2025-04-30 20:35 |
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Publication Fee Transferred |
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2025-05-12 04:33 |
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Second Decision by Editor |
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2025-06-25 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-07 09:06 |
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Articles in Press |
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2025-07-07 09:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-04 02:46 |
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Publish the Manuscript Online |
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2025-08-14 10:51 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Li, Ming Gao, Jia-Xin Wang, Hong-Yan Li, Pin Wang, Fang Yuan, Ai-Jing Liu and Song-Yun Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hebei Province |
No. H2021206187; and No. H2021206452 |
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| Corresponding Author |
Song-Yun Zhang, PhD, Department of Endocrinology, The Second Hospital of Hebei Medical University, Hepingxi Road, Shijiazhuang 050000, Hebei Province, China. zhangsongyun2014@126.com |
| Key Words |
Diabetic cognitive dysfunction; Transient receptor potential melastatin 7; Mitochondrial fission; Dynamin-related protein 1; Troxerutin; Morris water maze; Novel object recognition tasks; Nesting tests |
| Core Tip |
The expression of transient receptor potential melastatin 7 (TRPM7) was increased in diabetic cognitive dysfunction (DCD) mice and hippocampal neurons treated with high-concentration glucose. TRPM7 promoted mitochondrial fission in hippocampal neurons by upregulating calcineurin (CaN)/dynamin-related protein 1 (Drp1)ser637. The TRPM7/CaN/Drp1ser637 signaling pathway played an important role in DCD. Troxerutin improved DCD by inhibiting mitochondrial fission mediated by TRPM7/CaN/Drp1ser637. |
| Publish Date |
2025-08-14 10:51 |
| Citation |
Li J, Gao M, Wang JX, Li HY, Wang P, Yuan F, Liu AJ, Zhang SY. Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637. World J Diabetes 2025; 16(8): 106833 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i8/106833.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i8.106833 |
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