Publication Name	World Journal of Gastroenterology
Manuscript ID	106895
Country	China

Received	2025-03-11 10:31
Peer-Review Started	2025-03-11 10:31
To Make the First Decision
Return for Revision	2025-04-03 22:45
Revised	2025-04-15 11:36
Second Decision	2025-07-14 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-14 05:24
Articles in Press	2025-07-14 05:24
Publication Fee Transferred	2025-04-17 16:42
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-27 14:53
Publish the Manuscript Online	2025-08-05 08:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Flotillin-1 promotes the progression of hepatocellular carcinoma by activating TFE3-mediated Golgi stress response via inhibition of mTORC1/2
Manuscript Source	Unsolicited Manuscript
All Author List	Liang Zhang, Cheng-Zhi Bai, Jia-Yan Shan, Hong-Li Xue, Shu-Mei Zheng, Ya-Lun Chen and Shan-Hong Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82203806 General Hospital of Western Theater Command Project Funding 2024-YGJC-B10
Corresponding Author	Shan-Hong Tang, Academic Editor, Professor, Department of Gastroenterology, The General Hospital of Western Theater Command, No. 270 Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan Province, China. shanhongtang@163.com
Key Words	Hepatocellular carcinoma; Flotillin-1; Transcription factor E3; Golgi stress; Proliferation
Core Tip	Research has found a close correlation between Golgi apparatus function and the survival of cancer cells. This study elucidates that elevated expression of flotillin-1 (FLOT1) promotes the proliferation, migration, and invasion capabilities of hepatocellular carcinoma (HCC), as well as the mechanism by which FLOT1 inhibits mechanistic target of rapamycin complex 1/2 by ubiquitination, leading to the dephosphorylation and nuclear translocation of the transcription factor transcription factor E3, thereby activating the Golgi stress response and further promoting the malignant biological behavior of HCC. These findings underscore the potential of the lipid raft protein FLOT1 as a promising therapeutic target for HCC treatment in clinical practice.
Publish Date	2025-08-05 08:25
Citation	<p>Zhang L, Bai CZ, Shan JY, Xue HL, Zheng SM, Chen YL, Tang SH. Flotillin-1 promotes the progression of hepatocellular carcinoma by activating TFE3-mediated Golgi stress response via inhibition of mTORC1/2. <i>World J Gastroenterol</i> 2025; 31(29): 106895</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i29/106895.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i29.106895

Full Article (PDF)	WJG-31-106895-with-cover.pdf
The ARRIVE Guidelines	106895-The-ARRIVE-Guidelines.pdf
Manuscript File	106895_Auto_Edited_062604.docx
Answering Reviewers	106895-answering-reviewers.pdf
Audio Core Tip	106895-audio.wav
Biostatistics Review Certificate	106895-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106895-conflict-of-interest-statement.pdf
Copyright License Agreement	106895-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106895-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	106895-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	106895-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106895-non-native-speakers.pdf
Supplementary Material	106895-supplementary-material.pdf
Peer-review Report	106895-peer-reviews.pdf
Scientific Misconduct Check	106895-scientific-misconduct-check.png
Scientific Editor Work List	106895-scientific-editor-work-list.pdf
CrossCheck Report	106895-crosscheck-report.pdf