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6/23/2025 8:18:08 AM | Browse: 13 | Download: 27
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Received |
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2025-03-12 03:30 |
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Peer-Review Started |
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2025-03-12 03:30 |
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To Make the First Decision |
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Return for Revision |
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2025-04-18 01:49 |
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Revised |
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2025-04-21 20:05 |
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Second Decision |
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2025-06-05 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-07 02:51 |
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Articles in Press |
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2025-06-07 02:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 00:43 |
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Publish the Manuscript Online |
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2025-06-23 07:18 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Uptake of lumbar puncture and mortality among patients with advanced human immunodeficiency virus disease who screened for serum cryptococcal-antigen in Africa
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Haji Mbwana Ally, Hafidha Mhando Bakari, Jackline Vicent Mbishi, Zuhura Mbwana Ally, Mariam Salim Mbwana, Lynn Moshi, Rahma Musoke, Swalehe Mustafa Salim, Hassan Fredrick Fussi, Aboubakar Omar Mustafa, John Bartlet and Habib Omari Ramadhani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Habib Omari Ramadhani, MD, PhD, Department of Medicine, Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard Street, Baltimore, MD 21201, United States. homari@ihv.umaryland.edu |
| Key Words |
Lumbar puncture uptake; Cryptococcal antigen; Advanced human immunodeficiency virus disease; Mortality; Africa |
| Core Tip |
There is limited data on the compliance of the World Health Organization guideline on the management of patients with advanced human immunodeficiency virus (HIV) disease (AHD). This systematic review and meta-analysis analyzed 46890 people with AHD screened for serum cryptococcal antigen (CrAg) from 32 studies conducted in Africa between 2011 and 2024. Of those screened, 2730 tested positive for serum CrAg. The uptake of lumbar puncture (LP) procedure among those with positive serum CrAg was between 55% and 68%. Mortality was higher among those with positive serum CrAg compared to those with negative serum CrAg. In Africa, among people with AHD who screened positive for CrAg, uptake of LP procedure is low, indicating gaps in the diagnosis of cryptococcal meningitis. |
| Publish Date |
2025-06-23 07:18 |
| Citation |
<p>Ally HM, Bakari HM, Mbishi JV, Ally ZM, Mbwana MS, Moshi L, Musoke R, Salim SM, Fussi HF, Mustafa AO, Bartlet J, Ramadhani HO. Uptake of lumbar puncture and mortality among patients with advanced human immunodeficiency virus disease who screened for serum cryptococcal-antigen in Africa. <i>World J Virol</i> 2025; 14(2): 106973</p> |
| URL |
https://www.wjgnet.com/2220-3249/full/v14/i2/106973.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v14.i2.106973 |
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