| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
New advances in oral microbiology and tumor research
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hong-Jun Liang, Xian-Yi Tan, Di Li, Cheng Lin, Suo-Yi Huang, Guo-Chao Nie, Xue-Feng Guo, Zheng-Bao Zhang, Xiao-Nian Zhu and Sheng-Kui Tan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Science and Technology Research and Development Program Project of Guangxi |
GuikeAB22035017 |
| Key Science and Technology Research and Development Program Project of Guangxi |
GuikeAB25069071 |
|
| Corresponding Author |
Xiao-Nian Zhu, MD, Professor, Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Zhiyuan Road 1, Guilin 541199, Guangxi Zhuang Autonomous Region, China. zhuxiaonian0403@163.com |
| Key Words |
Oral microbiota; Tumorigenesis; Cancer; Microbial dysbiosis; Multi-omics integration; Precision medicine |
| Core Tip |
This review synthesizes recent progress in understanding the complex interactions between the oral microbiota and various cancers, particularly oral squamous cell carcinoma, esophageal adenocarcinoma, and pancreatic ductal adenocarcinoma. It highlights the roles of pathogenic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum in promoting tumor progression through chronic inflammation, metabolic toxin production, and immune evasion. The review also explores innovative therapeutic strategies, including probiotics, oral microbiota transplantation, and CRISPR-based bacterial editing, while emphasizing the potential of saliva-based microbial biomarkers for non-invasive cancer screening. This work aims to translate microbial-related research into clinical applications, with the goal of mitigating the global cancer burden through early diagnosis and microbiome-targeted therapy. |
| Publish Date |
2025-07-22 09:23 |
| Citation |
<p>Liang HJ, Tan XY, Li D, Lin C, Huang SY, Nie GC, Guo XF, Zhang ZB, Zhu XN, Tan SK. New advances in oral microbiology and tumor research. <i>World J Clin Oncol</i> 2025; 16(7): 106981</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i7/106981.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i7.106981 |
