Publication Name	World Journal of Diabetes
Manuscript ID	107017
Country	China

Received	2025-03-13 12:41
Peer-Review Started	2025-03-14 07:00
To Make the First Decision
Return for Revision	2025-03-20 08:16
Revised	2025-03-22 07:27
Second Decision	2025-04-02 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-02 05:34
Articles in Press	2025-04-02 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-10 09:26
Typeset the Manuscript	2025-05-29 14:23
Publish the Manuscript Online	2025-06-13 11:47

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng Luo, Zhi-Gang Zheng, Mei-Qi Zeng, Hui Xu, Xian-Mei Yu, Da Sun and Dong-Juan He
Funding Agency and Grant Number	Funding Agency Grant Number Quzhou Science and Technology Plan Project 2024K076
Corresponding Author	Dong-Juan He, Chief Physician, Deputy Director, MD, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin 'an Avenue, Qujiang District, Quzhou 324000, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn
Key Words	Curcumol; Diabetic retinopathy; Epigenetic regulation; FTO/MAFG-AS1 pathway; N6-methyladenosine modification; Metabolic memory; Nano-delivery system; Single-cell transcriptomics
Core Tip	This study reveals curcumol's dual-action mechanism in diabetic retinopathy through FTO/MAFG-AS1 axis modulation and macrophage membrane-coated nanodelivery. Curcumol activates FTO demethylase to stabilize MAFG-AS1, suppressing hyperglycemia-induced vascular leakage and inflammation. Single-cell transcriptomics resolve FTO's paradoxical roles: Promoting pathological angiogenesis in endothelial cells while exerting antioxidant/anti-inflammatory effects via MAFG-AS1. A multidimensional epigenetic network integrates N6-methyladenosine, histone lactylation, and DNA methylation. Biomimetic nanoparticles enhance retinal targeting and bioavailability. The paradigm shifts from reactive treatment to AI-guided prevention, emphasizing early intervention via metabolic memory disruption and multi-tiered clinical strategies. These findings advance precision therapy by synergizing epigenetics, nanotechnology, and systems biology.
Publish Date	2025-06-13 11:47
Citation	<p>Luo C, Zheng ZG, Zeng MQ, Xu H, Yu XM, Sun D, He DJ. Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation. <i>World J Diabetes</i> 2025; 16(6): 107017</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i6/107017.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i6.107017

Full Article (PDF)	WJD-16-107017-with-cover.pdf
Manuscript File	107017_Auto_Edited_041115.docx
Answering Reviewers	107017-answering-reviewers.pdf
Audio Core Tip	107017-audio.mp3
Conflict-of-Interest Disclosure Form	107017-conflict-of-interest-statement.pdf
Copyright License Agreement	107017-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107017-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	107017-non-native-speakers.pdf
Peer-review Report	107017-peer-reviews.pdf
Scientific Editor Work List	107017-scientific-editor-work-list.pdf
CrossCheck Report	107017-crosscheck-report.pdf