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7/17/2025 10:00:01 AM | Browse: 213 | Download: 569
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Received |
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2025-03-14 06:29 |
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Peer-Review Started |
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2025-03-14 06:29 |
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First Decision by Editorial Office Director |
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2025-04-01 08:56 |
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2025-04-01 08:56 |
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Revised |
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2025-04-14 12:29 |
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Publication Fee Transferred |
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2025-04-21 07:22 |
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Second Decision by Editor |
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2025-05-27 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-27 10:25 |
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Articles in Press |
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2025-05-27 10:25 |
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Edit the Manuscript by Language Editor |
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2025-05-28 04:34 |
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Typeset the Manuscript |
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2025-07-10 07:35 |
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Publish the Manuscript Online |
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2025-07-17 08:43 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Zheng Zhi, Tao Liu, Jian Kang, Fu-Chao Zhou, Xiao-Dong Liu and Zhi-Min He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Academic Subject Boosting Plan in Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine |
SY-XKZT-2019-3002 |
| Academic Project from the Health Commission of Hongkou District, Shanghai |
2202-25 |
| clinical key specialty construction unit from the Health Commission of Hongkou District, Shanghai |
HKLCZD2024B03 |
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| Corresponding Author |
Zhi-Min He, Department of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai Fourth People's Hospital, Shanghai 200434, China. zzz0327@tongji.edu.cn |
| Key Words |
Degenerative disk disease; Nucleus pulposus cell; MiR-365; HOXA9; HIF-1α |
| Core Tip |
This study investigates the role of miR-365 in promoting the differentiation of bone marrow mesenchymal stem cells (MSCs) into nucleus pulposus cells (NPCs) for degenerative disk disease (DDD) treatment. We reveal that miR-365 enhances MSC proliferation and inhibits apoptosis, while promoting NPC-related marker expression. Mechanistically, miR-365 targets HOXA9, which in turn regulates HIF-1α, Sox9, and Kdm6a. This finding highlights miR-365 as a potential therapeutic target for DDD, offering a novel strategy to address the loss of NPCs |
| Publish Date |
2025-07-17 08:43 |
| Citation |
Zhi ZZ, Liu T, Kang J, Zhou FC, Liu XD, He ZM. miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α. World J Orthop 2025; 16(7): 107045 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i7/107045.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i7.107045 |
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