Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	107052
Country	Pakistan

Received	2025-03-14 06:45
Peer-Review Started	2025-03-14 06:46
To Make the First Decision
Return for Revision	2025-03-26 13:27
Revised	2025-04-09 04:45
Second Decision	2025-04-21 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 09:05
Articles in Press	2025-04-21 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-10 07:01
Publish the Manuscript Online	2025-06-19 08:18

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Yasir Raza, Muhammed Mubarak, Muhammad Yousuf Memon and Mohammed Saud Alsulaimi
Funding Agency and Grant Number
Corresponding Author	Muhammed Mubarak, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Key Words	Helicobacter pylori; Molecular pathogenesis; Gastric cancer; DNA repair; mutations
Core Tip	Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer (GC), the third leading cause of cancer-related deaths. H. pylori triggers chronic inflammation, progressing through precancerous stages (gastritis, atrophy, intestinal metaplasia, dysplasia) to GC. Virulence factors like cytotoxin-associated gene A and vacuolating cytotoxin A activate oncogenic signaling pathways (PI3K/Akt, JAK/STAT, Ras/Raf/ERK), promoting uncontrolled cell proliferation and impairing DNA repair, leading to carcinogenic mutations. While 1%-3% of infected individuals develop GC, understanding these molecular mechanisms is crucial for identifying diagnostic markers and developing targeted therapies. This review explores H. pylori's role in gastric carcinogenesis, emphasizing bacterial-host interactions and potential preventive strategies.
Publish Date	2025-06-19 08:18
Citation	<p>Raza Y, Mubarak M, Memon MY, Alsulaimi MS. Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer. <i>World J Gastrointest Pathophysiol</i> 2025; 16(2): 107052</p>
URL	https://www.wjgnet.com/2150-5330/full/v16/i2/107052.htm
DOI	https://dx.doi.org/10.4291/wjgp.v16.i2.107052

Full Article (PDF)	WJGP-16-107052-with-cover.pdf
Manuscript File	107052_Auto_Edited_073558.docx
Answering Reviewers	107052-answering-reviewers.pdf
Audio Core Tip	107052-audio.opus
Conflict-of-Interest Disclosure Form	107052-conflict-of-interest-statement.pdf
Copyright License Agreement	107052-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107052-non-native-speakers.pdf
Supplementary Material	107052-supplementary-material.pdf
Peer-review Report	107052-peer-reviews.pdf
Scientific Editor Work List	107052-scientific-editor-work-list.pdf
CrossCheck Report	107052-crosscheck-report.pdf