Publication Name	World Journal of Gastroenterology
Manuscript ID	107100
Country	Peru

Received	2025-03-16 05:16
Peer-Review Started	2025-03-16 05:16
To Make the First Decision
Return for Revision	2025-04-10 20:05
Revised	2025-04-22 17:08
Second Decision	2025-05-27 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-27 06:39
Articles in Press	2025-05-27 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-04 18:42
Typeset the Manuscript	2025-06-16 03:00
Publish the Manuscript Online	2025-06-20 09:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatocellular carcinoma in non-cirrhotic patients
Manuscript Source	Invited Manuscript
All Author List	Karina Sato-Espinoza, Mayra Valdivia-Herrera, Perapa Chotiprasidhi and Javier Diaz-Ferrer
Funding Agency and Grant Number
Corresponding Author	Javier Diaz-Ferrer, Associate Professor, MD, Hepatology Service, Department of Digestive Diseases, Hospital Nacional Edgardo Rebagliati Martins, 490 Edgardo Rebagliati Avenue, Lima 15072, Peru. jodf13@hotmail.com
Key Words	Hepatocellular carcinoma; Non-cirrhotic; Metabolic dysfunction-associated steatotic liver disease; Hepatitis B; Hepatitis C; Aflatoxin
Core Tip	Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and the incidence of HCC among non-cirrhotic individuals is on the rise, correlating with increasing rates of obesity and metabolic syndrome. Targeted surveillance is advised for high-risk groups, especially those with chronic hepatitis B infection, while it remains unrecommended for individuals with metabolic dysfunction-associated steatotic liver disease. Liver biopsy is the only diagnostic method available for this population, highlighting the need for further non-invasive diagnostic tools. This review aims to summarize the epidemiology, clinical and genetic characteristics, diagnostic methods, and treatment options for non-cirrhotic individuals with HCC.
Publish Date	2025-06-20 09:55
Citation	<p>Sato-Espinoza K, Valdivia-Herrera M, Chotiprasidhi P, Diaz-Ferrer J. Hepatocellular carcinoma in non-cirrhotic patients. <i>World J Gastroenterol</i> 2025; 31(23): 107100</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i23/107100.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i23.107100

Full Article (PDF)	WJG-31-107100-with-cover.pdf
Manuscript File	107100_Auto_Edited_055207.docx
Answering Reviewers	107100-answering-reviewers.pdf
Audio Core Tip	107100-audio.wav
Conflict-of-Interest Disclosure Form	107100-conflict-of-interest-statement.pdf
Copyright License Agreement	107100-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107100-non-native-speakers.pdf
Supplementary Material	107100-supplementary-material.pdf
Peer-review Report	107100-peer-reviews.pdf
Scientific Misconduct Check	107100-scientific-misconduct-check.png
Scientific Editor Work List	107100-scientific-editor-work-list.pdf
CrossCheck Report	107100-crosscheck-report.pdf