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6/26/2025 10:14:50 AM | Browse: 281 | Download: 1244
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Received |
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2025-03-21 02:05 |
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Peer-Review Started |
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2025-03-31 00:10 |
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First Decision by Editorial Office Director |
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2025-04-11 09:57 |
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Return for Revision |
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2025-04-11 09:57 |
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Revised |
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2025-04-24 17:30 |
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Publication Fee Transferred |
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2025-04-26 13:31 |
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Second Decision by Editor |
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2025-05-29 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-29 10:19 |
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Articles in Press |
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2025-05-29 10:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 07:45 |
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Publish the Manuscript Online |
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2025-06-26 07:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Li Xi, Yi-Dong Yang, Hui-Ling Liu, Jie Jiang and Bin Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Project of Guangzhou |
No. 2024A03J0102 |
| Natural Science Foundation of Guangdong Province for Distinguished Young Scholar |
No. 2022B1515020024 |
| National Natural Science Foundation of China |
No. 82070574 |
| Key Research and Development Program of Guangzhou |
No. 2023B03J1298 |
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| Corresponding Author |
Bin Wu, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. wubin6@mail.sysu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Single-cell multiomics; Chromatin accessibility; Enhancer-like peak; Chromatin coaccessibility |
| Core Tip |
This study unveils multilayered chromatin accessibility dynamics in hepatocellular carcinoma. Single-cell multiomics analysis discovered malignant hepatocytes adopting increased numbers of accessible peaks and larger physical regions despite reduced peak intensity, while tumor-stroma intercellular chromatin coaccessibility maintains tumor ecological symbiosis. Functional validation identified DGAT1 as an epigenetic vulnerability: Pharmacological histone 3 lysine 27 acetylation inhibition and relating decreased chromatin accessibility suppressed DGAT1 expression, and DGAT1 knockdown further blocked tumor growth. Our findings redefine hepatocellular carcinoma progression as a chromatin-adaptive disorder governed by tumor-intrinsic epigenetic prioritization and microenvironmental crosstalk, proposing simultaneous targeting of chromatin hub genes and compensatory pathways as precision strategies. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
Xi XL, Yang YD, Liu HL, Jiang J, Wu B. Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma. World J Hepatol 2025; 17(6): 107329
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| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/107329.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.107329 |
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