Publication Name	World Journal of Hepatology
Manuscript ID	107329
Country	China

Received	2025-03-21 02:05
Peer-Review Started	2025-03-31 00:10
To Make the First Decision
Return for Revision	2025-04-11 09:57
Revised	2025-04-24 17:30
Second Decision	2025-05-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-29 10:19
Articles in Press	2025-05-29 10:19
Publication Fee Transferred	2025-04-26 13:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-16 07:45
Publish the Manuscript Online	2025-06-26 07:27

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Li Xi, Yi-Dong Yang, Hui-Ling Liu, Jie Jiang and Bin Wu
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Project of Guangzhou No. 2024A03J0102 Natural Science Foundation of Guangdong Province for Distinguished Young Scholar No. 2022B1515020024 National Natural Science Foundation of China No. 82070574 Key Research and Development Program of Guangzhou No. 2023B03J1298
Corresponding Author	Bin Wu, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. wubin6@mail.sysu.edu.cn
Key Words	Hepatocellular carcinoma; Single-cell multiomics; Chromatin accessibility; Enhancer-like peak; Chromatin coaccessibility
Core Tip	This study unveils multilayered chromatin accessibility dynamics in hepatocellular carcinoma. Single-cell multiomics analysis discovered malignant hepatocytes adopting increased numbers of accessible peaks and larger physical regions despite reduced peak intensity, while tumor-stroma intercellular chromatin coaccessibility maintains tumor ecological symbiosis. Functional validation identified DGAT1 as an epigenetic vulnerability: Pharmacological histone 3 lysine 27 acetylation inhibition and relating decreased chromatin accessibility suppressed DGAT1 expression, and DGAT1 knockdown further blocked tumor growth. Our findings redefine hepatocellular carcinoma progression as a chromatin-adaptive disorder governed by tumor-intrinsic epigenetic prioritization and microenvironmental crosstalk, proposing simultaneous targeting of chromatin hub genes and compensatory pathways as precision strategies.
Publish Date	2025-06-26 07:27
Citation	<p>Xi XL, Yang YD, Liu HL, Jiang J, Wu B. Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma. <i>World J Hepatol</i> 2025; 17(6): 107329</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i6/107329.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i6.107329

Full Article (PDF)	WJH-17-107329-with-cover.pdf
Manuscript File	107329_Auto_Edited_021954.docx
Answering Reviewers	107329-answering-reviewers.pdf
Audio Core Tip	107329-audio.mp3
Biostatistics Review Certificate	107329-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107329-conflict-of-interest-statement.pdf
Copyright License Agreement	107329-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107329-foundation-statement.pdf
Institutional Review Board Approval Form or Document	107329-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	107329-non-native-speakers.pdf
Supplementary Material	107329-supplementary-material.pdf
Peer-review Report	107329-peer-reviews.pdf
Scientific Misconduct Check	107329-scientific-misconduct-check.png
Scientific Editor Work List	107329-scientific-editor-work-list.pdf
CrossCheck Report	107329-crosscheck-report.pdf