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6/6/2025 6:59:32 AM | Browse: 303 | Download: 640
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2025-03-23 16:57 |
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2025-03-23 16:57 |
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2025-05-23 02:42 |
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2025-05-23 06:54 |
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Typeset the Manuscript |
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Publish the Manuscript Online |
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2025-06-06 03:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You Zhang, Yi-Wen Tang, Jin Zhou, Yan-Rong Wei, Yu-Ting Peng, Zi Yan and Zeng-Hui Yue |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hunan Province, China |
No. 2023JJ30462 |
| Hunan Provincial Department of Science and Technology |
No. 2023SK2045 |
| Hunan Provincial Department of Science and Technology |
No. 22JBZ007 |
| Hunan Provincial Department of Science and Technology |
No. Z2023JB01 |
| Graduate Research and Innovation Projects of Hunan Province |
No. 2024CX031 |
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| Corresponding Author |
Zeng-Hui Yue, FACE, College of Acupuncture, Massage and Rehabilitation, Hunan University of Chinese Medicine, No. 300 Bachelor Road, Yuelu District, Changsha 410208, Hunan Province, China. yue5381316@126.com |
| Key Words |
Electroacupuncture; Diabetic gastroparesis; Vagus nerve; Gastric motility; Interstitial cells of Cajal; Positron emission tomography-computed tomography imaging |
| Core Tip |
Multimodal validation: Electroacupuncture (EA) significantly enhanced gastric emptying (validated by positron emission tomography-computed tomography), restored gastric slow-wave rhythms, and improved smooth muscle architecture via upregulation of neuronal nitric oxide synthase, cluster of differentiation 117, stem cell factor. Mechanistic insight: EA activates cholinergic targets (choline acetyltransferas/α7 nicotinic acetylcholine receptor) at ST36, transmits signals via spinal L4-L6 afferents to the nucleus tractus solitarius, and modulates gastrointestinal peptides (ghrelin, motilin, vasoactive intestinal peptide) through subdiaphragmatic vagal efferents, ultimately restoring interstitial cells of Cajal function. Translational relevance: Subdiaphragmatic vagotomy abolished EA’s therapeutic effects, unequivocally establishing vagal efferent signaling as indispensable. |
| Publish Date |
2025-06-06 03:09 |
| Citation |
Zhang Y, Tang YW, Zhou J, Wei YR, Peng YT, Yan Z, Yue ZH. Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. World J Gastroenterol 2025; 31(21): 107395
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| URL |
https://www.wjgnet.com/1007-9327/full/v31/i21/107395.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i21.107395 |
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