Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107412
Country	China

Received	2025-03-26 03:26
Peer-Review Started	2025-03-26 03:26
To Make the First Decision
Return for Revision	2025-04-09 11:09
Revised	2025-05-05 10:52
Second Decision	2025-06-19 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-19 07:00
Articles in Press	2025-06-19 07:00
Publication Fee Transferred	2025-05-13 06:57
Edit the Manuscript by Language Editor	2025-06-22 09:45
Typeset the Manuscript	2025-08-01 01:29
Publish the Manuscript Online	2025-08-14 05:49

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Yu Huang, Jiang Lan and Wei Zhuang
Funding Agency and Grant Number
Corresponding Author	Wei Zhuang, MD, Intensive Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No.1 Jingbaji Road, Shizhong District, Jinan 250000, Shandong Province, China. 18364155005@163.com
Key Words	Gastric neoplasms; DNA methylation; Circulating tumor DNA; Biomarkers; Early screening
Core Tip	Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker for early cancer detection and monitoring. Aberrant DNA methylation is one of the earliest and most frequent epigenetic alterations in gastric cancer. This review summarizes recent advances in understanding the role of ctDNA methylation in gastric cancer initiation, progression, and potential clinical applications. We highlight the advantages of ctDNA methylation analysis in disease diagnosis, prognosis prediction, and therapeutic monitoring. A better understanding of ctDNA methylation dynamics may provide new insights into personalized medicine and improve outcomes in patients with gastric cancer.
Publish Date	2025-08-14 05:49
Citation	<p>Huang HY, Lan J, Zhuang W. Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review. <i>World J Gastrointest Oncol</i> 2025; 17(8): 107412</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i8/107412.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i8.107412

Full Article (PDF)	WJGO-17-107412-with-cover.pdf
Manuscript File	107412_Auto_Edited_073151.docx
Answering Reviewers	107412-answering-reviewers.pdf
Audio Core Tip	107412-audio.mp3
Conflict-of-Interest Disclosure Form	107412-conflict-of-interest-statement.pdf
Copyright License Agreement	107412-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107412-non-native-speakers.pdf
Supplementary Material	107412-supplementary-material.pdf
Peer-review Report	107412-peer-reviews.pdf
Scientific Misconduct Check	107412-scientific-misconduct-check.png
Scientific Editor Work List	107412-scientific-editor-work-list.pdf
CrossCheck Report	107412-crosscheck-report.pdf