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7/10/2025 6:37:06 AM | Browse: 5 | Download: 31
Publication Name World Journal of Psychiatry
Manuscript ID 107524
Country China
Received
2025-03-30 10:49
Peer-Review Started
2025-04-06 08:18
To Make the First Decision
Return for Revision
2025-04-09 12:09
Revised
2025-04-23 03:20
Second Decision
2025-05-12 10:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-19 09:23
Articles in Press
2025-05-19 09:23
Publication Fee Transferred
2025-04-24 02:28
Edit the Manuscript by Language Editor
2025-05-27 01:45
Typeset the Manuscript
2025-06-21 03:15
Publish the Manuscript Online
2025-07-10 03:52
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Basic Study
Article Title DNA methylation regulates the extinction of fear memory
Manuscript Source Unsolicited Manuscript
All Author List Le Jiang, Rui-Xue Ma, Er-Shu He, Xiao-Ye Zheng, Xin Peng, Wen-Hao Ma, Ying Li, Han-Wei Li, Xue-Yan Zhang, Jie-Yu Ji, Yan-Jiao Li, Shang-Lan Qu, Li-Juan Li and Zhi-Ting Gong
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 82360231
Yunnan Basic Research Program General Project 202401AT070075
Dali Basic Research Program Key Project 202301A020021
Youth Special Project for Basic Research of Local Universities in Yunnan Province 202301BA070001-127
Corresponding Author Zhi-Ting Gong, Associate Professor, School of Medicine, Dali university, No. 2 Hongsheng Road, Dali 671003, Yunnan Province, China. gzhting@foxmail.com
Key Words RG108; DNA methylation; Fear memory; Exposure therapy; Extinction
Core Tip Reduce methylation by RG108 suppressed extinction, reduced spine density, and inhibited neuronal activity; enhancing methylation by L-methionine improve the efficacy of exposure therapy, offering a potential strategy for treating fear-related disorders.
Publish Date 2025-07-10 03:52
Citation <p>Jiang L, Ma RX, He ES, Zheng XY, Peng X, Ma WH, Li Y, Li HW, Zhang XY, Ji JY, Li YJ, Qu SL, Li LJ, Gong ZT. DNA methylation regulates the extinction of fear memory. <i>World J Psychiatry</i> 2025; 15(7): 107524</p>
URL https://www.wjgnet.com/2220-3206/full/v15/i7/107524.htm
DOI https://dx.doi.org/10.5498/wjp.v15.i7.107524
Full Article (PDF) WJP-15-107524-with-cover.pdf
The ARRIVE Guidelines 107524-The-ARRIVE-Guidelines.pdf
Manuscript File 107524_Auto_Edited_040836.docx
Answering Reviewers 107524-answering-reviewers.pdf
Audio Core Tip 107524-audio.wav
Biostatistics Review Certificate 107524-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 107524-conflict-of-interest-statement.pdf
Copyright License Agreement 107524-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 107524-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 107524-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 107524-non-native-speakers.pdf
Supplementary Material 107524-supplementary-material.zip
Peer-review Report 107524-peer-reviews.pdf
Scientific Misconduct Check 107524-scientific-misconduct-check.png
Scientific Editor Work List 107524-scientific-editor-work-list.pdf
CrossCheck Report 107524-crosscheck-report.pdf