| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
DNA methylation regulates the extinction of fear memory
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Le Jiang, Rui-Xue Ma, Er-Shu He, Xiao-Ye Zheng, Xin Peng, Wen-Hao Ma, Ying Li, Han-Wei Li, Xue-Yan Zhang, Jie-Yu Ji, Yan-Jiao Li, Shang-Lan Qu, Li-Juan Li and Zhi-Ting Gong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
82360231 |
| Yunnan Basic Research Program General Project |
202401AT070075 |
| Dali Basic Research Program Key Project |
202301A020021 |
| Youth Special Project for Basic Research of Local Universities in Yunnan Province |
202301BA070001-127 |
|
| Corresponding Author |
Zhi-Ting Gong, Associate Professor, School of Medicine, Dali university, No. 2 Hongsheng Road, Dali 671003, Yunnan Province, China. gzhting@foxmail.com |
| Key Words |
RG108; DNA methylation; Fear memory; Exposure therapy; Extinction |
| Core Tip |
Reduce methylation by RG108 suppressed extinction, reduced spine density, and inhibited neuronal activity; enhancing methylation by L-methionine improve the efficacy of exposure therapy, offering a potential strategy for treating fear-related disorders. |
| Publish Date |
2025-07-10 03:52 |
| Citation |
<p>Jiang L, Ma RX, He ES, Zheng XY, Peng X, Ma WH, Li Y, Li HW, Zhang XY, Ji JY, Li YJ, Qu SL, Li LJ, Gong ZT. DNA methylation regulates the extinction of fear memory. <i>World J Psychiatry</i> 2025; 15(7): 107524</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i7/107524.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i7.107524 |
