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6/20/2025 10:22:47 AM | Browse: 21 | Download: 28
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Received |
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2025-03-27 02:50 |
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Peer-Review Started |
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2025-03-27 02:50 |
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To Make the First Decision |
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Return for Revision |
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2025-04-16 06:00 |
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2025-04-23 14:50 |
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Second Decision |
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2025-05-12 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-12 04:56 |
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Articles in Press |
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2025-05-12 04:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 03:03 |
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Publish the Manuscript Online |
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2025-06-20 09:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Activation of lymphangiogenesis by platelet as novel therapeutic approaches for liver cirrhosis and portal hypertension
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian-Fu Li, Qing-Bo Wang, Yu-Kai Li, Yu-Bo Liang, Xing-Ming Chen, Qi-Yu Lu and Yang Ke |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82460461 |
| Medical Subject Leader of Yunnan Province (General Surgery) |
No. D-2024029 |
| Yunnan Fundamental Research Project for Excellent Young Scholars |
No. 202401AW070003 |
| The Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province |
No. 202205AC160063 |
| Beijing Bethune Charitable Foundation |
No. STLKY0089 |
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| Corresponding Author |
Yang Ke, Assistant Professor, Director, MD, PhD, Division of Hepatobiliary Surgery, Department of Surgical Education and Research, The Second Affiliated Hospital of Kunming Medical University, No. 374 Kunrui Road, Wuhua District, Kunming 650101, Yunnan, China. keyang1218@126.com |
| Key Words |
Portal hypertension; Liver cirrhosis; Lymphangiogenesis; Platelets; Vascular endothelial growth factor C |
| Core Tip |
Whole-transcriptome sequencing in rat model of liver cirrhosis induced by bile duct ligation revealed the strong link between lymphangiogenesis and the process of platelet adherence, aggregation, and activation. Gain and loss of function approach confirmed the crucial function of lymphangiogenesis in the development of liver cirrhosis and portal hypertension (PHT). In conclusion, this study provides support for the application of platelet transfusion or pharmacological intervention of lymphangiogenesis as novel therapeutic approaches for liver cirrhosis and PHT. |
| Publish Date |
2025-06-20 09:55 |
| Citation |
<p>Li JF, Wang QB, Li YK, Liang YB, Chen XM, Lu QY, Ke Y. Activation of lymphangiogenesis by platelet as novel therapeutic approaches for liver cirrhosis and portal hypertension. <i>World J Gastroenterol</i> 2025; 31(23): 107554</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i23/107554.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i23.107554 |
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