Publication Name	World Journal of Stem Cells
Manuscript ID	107639
Country	China

Received	2025-03-28 04:29
Peer-Review Started	2025-03-28 04:29
To Make the First Decision
Return for Revision	2025-05-13 12:25
Revised	2025-05-26 12:46
Second Decision	2025-07-07 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-14 10:14
Articles in Press	2025-07-14 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-13 02:32
Publish the Manuscript Online	2025-08-21 05:29

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Roles of intestinal stem cells in inflammatory bowel disease pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Meng-Jie Zhang, Shi-Xin Chan, Ze-Guo Jia, Chuang Lv, Jia-Jie Chen and Shao-Cheng Hong
Funding Agency and Grant Number
Corresponding Author	Shao-Cheng Hong, MD, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 81 Meishan Road, Hefei 230022, Anhui Province, China. hscahmu@163.com
Key Words	Intestinal stem cells; Inflammatory bowel disease; Pathogenesis; Therapy potential; Clinical application
Core Tip	Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract that severely compromises the quality of life of patients. Intestinal stem cell proliferation and differentiation underlie damaged mucosa repair. However, mucosal healing - a key IBD therapeutic target - remains elusive with current treatments. Emerging stem cell therapy promotes mucosal barrier restoration, offering IBD intervention. This review examines intestinal stem cell roles in IBD pathogenesis and discusses specifically engineered stem cell-based therapies for management.
Publish Date	2025-08-21 05:29
Citation	<p>Zhang MJ, Chan SX, Jia ZG, Lv C, Chen JJ, Hong SC. Roles of intestinal stem cells in inflammatory bowel disease pathogenesis. <i>World J Stem Cells</i> 2025; 17(8): 107639</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i8/107639.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i8.107639

Full Article (PDF)	WJSC-17-107639-with-cover.pdf
Manuscript File	107639_Auto_Edited_072148.docx
Answering Reviewers	107639-answering-reviewers.pdf
Audio Core Tip	107639-audio.mp3
Conflict-of-Interest Disclosure Form	107639-conflict-of-interest-statement.pdf
Copyright License Agreement	107639-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107639-non-native-speakers.pdf
Supplementary Material	107639-supplementary-material.pdf
Peer-review Report	107639-peer-reviews.pdf
Scientific Misconduct Check	107639-scientific-misconduct-check.png
Scientific Editor Work List	107639-scientific-editor-work-list.pdf
CrossCheck Report	107639-crosscheck-report.pdf