Publication Name	World Journal of Gastroenterology
Manuscript ID	107703
Country	Germany

Received	2025-04-07 02:50
Peer-Review Started	2025-04-07 02:50
To Make the First Decision
Return for Revision	2025-04-20 03:42
Revised	2025-05-18 14:50
Second Decision	2025-08-22 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 07:39
Articles in Press	2025-08-22 07:39
Publication Fee Transferred	2025-06-02 14:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-11 06:45
Publish the Manuscript Online	2025-09-19 07:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Critical flicker frequency improves after alcohol detoxification and is associated with liver stiffness
Manuscript Source	Unsolicited Manuscript
All Author List	Omar Elshaarawy, Shuai Lan, Johannes Mueller and Sebastian Mueller
Funding Agency and Grant Number
Corresponding Author	Sebastian Mueller, PhD, Professor, Center for Alcohol Research, University of Heidelberg, In Neuenheimer Feld 350, Heidelberg 69120, Baden-Württemberg, Germany. sebastian.mueller@urz.uni-heidelberg.de
Key Words	Critical flicker frequency; Hepatic encephalopathy; Alcohol-related liver disease; Fibrosis; Cirrhosis; Transient elastography; Liver stiffness
Core Tip	This study demonstrates that critical flicker frequency (CFF), a non-invasive marker of neurocognitive function, significantly improves following alcohol detoxification in patients with alcohol-related liver disease (ALD). CFF was reduced in ALD patients and correlated with liver stiffness, particularly post-detoxification, highlighting its utility in detecting minimal hepatic encephalopathy. These findings underscore CFF’s value in assessing alcohol-related neurotoxicity and monitoring therapeutic response, supporting its integration into routine evaluation of patients with ALD and cirrhosis.
Publish Date	2025-09-19 07:57
Citation	<p>Elshaarawy O, Lan S, Mueller J, Mueller S. Critical flicker frequency improves after alcohol detoxification and is associated with liver stiffness. <i>World J Gastroenterol</i> 2025; 31(36): 107703</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i36/107703.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i36.107703

Full Article (PDF)	WJG-31-107703-with-cover.pdf
STROBE Statement	107703-STROBE-statement.pdf
Manuscript File	107703_Auto_Edited_031744.docx
Answering Reviewers	107703-answering-reviewers.pdf
Audio Core Tip	107703-audio.mp3
Biostatistics Review Certificate	107703-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107703-conflict-of-interest-statement.pdf
Copyright License Agreement	107703-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	107703-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	107703-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	107703-non-native-speakers.pdf
Peer-review Report	107703-peer-reviews.pdf
Scientific Misconduct Check	107703-scientific-misconduct-check.png
Scientific Editor Work List	107703-scientific-editor-work-list.pdf
CrossCheck Report	107703-crosscheck-report.pdf