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8/5/2025 9:52:55 AM | Browse: 52 | Download: 105
Publication Name World Journal of Gastroenterology
Manuscript ID 107745
Country Brazil
Received
2025-03-30 11:27
Peer-Review Started
2025-03-30 11:27
To Make the First Decision
Return for Revision
2025-05-20 19:38
Revised
2025-06-03 01:59
Second Decision
2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-11 05:33
Articles in Press
2025-07-11 05:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-07-27 14:53
Publish the Manuscript Online
2025-08-05 08:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Positioning and sequencing of advanced therapies in inflammatory bowel disease: A guide for clinical practice
Manuscript Source Invited Manuscript
All Author List Marcello Imbrizi, Matheus F C Azevedo, Julio P Baima, Natália S F Queiroz, Rogério S Parra, Sandro D C Ferreira, Ligia Y Sassaki and Julio Maria F Chebli
Funding Agency and Grant Number
Corresponding Author Julio Maria F Chebli, Adjunct Associate Professor, MD, PhD, Senior Researcher, Division of Gastroenterology, Department of Medicine, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine, Maria José Leal Street, 296, Juiz de Fora 36036-247, Minas Gerais, Brazil. julio.chebli@ufjf.br
Key Words Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Advanced therapy; Biologics; Sequencing; Treatment strategy; Janus kinase inhibitors; Biologic agents
Core Tip One of the key challenges clinicians face in managing individuals with inflammatory bowel disease (IBD) is determining which advanced therapy to initiate and how to sequence treatments when needed. In the absence of readily available molecular markers, these decisions, although often complex, are guided by patient- and disease-specific factors, including disease severity, phenotype, complication risk, comorbidities, extraintestinal manifestations, the balance between drug efficacy and safety, convenience, and treatment access. In this review, we examine the various considerations influencing therapeutic decision-making in different IBD clinical contexts and offer practical tips to support more personalized approaches based on the individual’s clinical profile.
Publish Date 2025-08-05 08:25
Citation <p>Imbrizi M, Azevedo MFC, Baima JP, Queiroz NSF, Parra RS, Ferreira SDC, Sassaki LY, Chebli JMF. Positioning and sequencing of advanced therapies in inflammatory bowel disease: A guide for clinical practice. <i>World J Gastroenterol</i> 2025; 31(29): 107745</p>
URL https://www.wjgnet.com/1007-9327/full/v31/i29/107745.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i29.107745
Full Article (PDF) WJG-31-107745-with-cover.pdf
Manuscript File 107745_Auto_Edited_062603.docx
Answering Reviewers 107745-answering-reviewers.pdf
Audio Core Tip 107745-audio.ogg
Conflict-of-Interest Disclosure Form 107745-conflict-of-interest-statement.pdf
Copyright License Agreement 107745-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 107745-non-native-speakers.pdf
Peer-review Report 107745-peer-reviews.pdf
Scientific Misconduct Check 107745-scientific-misconduct-check.png
Scientific Editor Work List 107745-scientific-editor-work-list.pdf
CrossCheck Report 107745-crosscheck-report.pdf