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12/19/2025 8:46:47 AM | Browse: 357 | Download: 1095
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2025-04-02 08:44 |
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2025-08-14 08:35 |
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Typeset the Manuscript |
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2025-12-08 00:46 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Sport Sciences |
| Manuscript Type |
Prospective Study |
| Article Title |
Association of inflammatory, genetic, and epigenetic markers with Kellgren-Lawrence grading in post-traumatic osteoarthritis of knee: A protocol
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keerthy Rethinam Meenakshi Sundaram, Thiagarajan Keddin Alwar, Ramchand Nannapan, Vinodhini Vellore Mohanakrishnan and Santhi Silambanan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| ICMR |
U04M200059 |
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| Corresponding Author |
Santhi Silambanan, MD, Professor, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116, Tamil Nādu, India. santhisilambanan@sriramachandra.edu.in |
| Key Words |
Biomarkers; Cytokines; Inflammation; Knee joint; Osteoarthritis |
| Core Tip |
Post-traumatic osteoarthritis (PTOA) is a secondary osteoarthritis that follows a joint injury. The knee is the most frequently affected joint, and the extent of injury ranges from simple to complex. PTOA is characterized by joint pain, swelling, and restricted movement. It is diagnosed beyond stage 2 of the Kellgren-Lawrence grading system, as evidenced by an X-ray. The disease begins after the joint injury, which further progresses due to complex biochemical interactions of cytokines, oxidative stress markers, enzymes, and collagen breakdown products. These markers can help us in a multidisciplinary approach thus emphasizing early intervention, biomarker-guided therapies, and mechanical stabilization thus, improving patient outcomes. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Sundaram KRM, Alwar TK, Nannapan R, Mohanakrishnan VV, Silambanan S. Association of inflammatory, genetic, and epigenetic markers with Kellgren-Lawrence grading in post-traumatic osteoarthritis of knee: A protocol. World J Exp Med 2025; 15(4): 107843
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| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/107843.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.107843 |
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