Publication Name	World Journal of Clinical Cases
Manuscript ID	107907
Country	Türkiye

Received	2025-04-02 07:02
Peer-Review Started	2025-04-02 07:02
To Make the First Decision
Return for Revision	2025-04-09 10:04
Revised	2025-04-15 20:03
Second Decision	2025-05-26 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-26 08:14
Articles in Press	2025-05-26 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-06 03:00
Publish the Manuscript Online	2025-07-07 05:58

ISSN	2307-8960 (online)
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Category	Physiology
Manuscript Type	Review
Article Title	Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview
Manuscript Source	Invited Manuscript
All Author List	Sadettin Demirel and Ipek Nazli Sinag
Funding Agency and Grant Number
Corresponding Author	Sadettin Demirel, Associate Professor, PhD, Medicine School, Physiology Department, Bursa Uludag University, Bursa 16059, Türkiye. sdemirel@uludag.edu.tr
Key Words	Endothelins; Lung cancer; Nitric oxide; Prostaglandins; Thromboxanes
Core Tip	Lung cancer remains the leading cause of cancer-related deaths globally. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) significantly influence lung carcinogenesis by modulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. This study highlights the dual roles of NO, the opposing effects of arachidonic acid-derived PGs, the involvement of TXA2 and its metabolite TXB2, and the critical functions of ETs in lung cancer progression. The findings emphasize the complex interplay of these agents in tumor biology, offering insights for potential therapeutic targets.
Publish Date	2025-07-07 05:58
Citation	<p>Demirel S, Sinag IN. Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview. <i>World J Clin Cases</i> 2025; 13(25): 107907</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i25/107907.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i25.107907

Full Article (PDF)	WJCC-13-107907-with-cover.pdf
Manuscript File	107907_Auto_Edited_040649.docx
Answering Reviewers	107907-answering-reviewers.pdf
Audio Core Tip	107907-audio.mp3
Conflict-of-Interest Disclosure Form	107907-conflict-of-interest-statement.pdf
Copyright License Agreement	107907-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	107907-non-native-speakers.pdf
Peer-review Report	107907-peer-reviews.pdf
Scientific Editor Work List	107907-scientific-editor-work-list.pdf
CrossCheck Report	107907-crosscheck-report.pdf