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9/19/2025 9:49:46 AM | Browse: 71 | Download: 58
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Received |
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2025-04-02 07:41 |
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Peer-Review Started |
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2025-04-02 07:42 |
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To Make the First Decision |
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Return for Revision |
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2025-05-09 12:15 |
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Revised |
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2025-05-19 06:05 |
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Second Decision |
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2025-08-01 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-01 11:28 |
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Articles in Press |
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2025-08-01 11:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-09 02:00 |
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Publish the Manuscript Online |
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2025-09-19 09:29 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Omer Abdelgadir, Yong-Fang Kuo, M Firoze Khan, Anthony O Okorodudu, Yu-Wei O Cheng and Jianli Dong |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jianli Dong, Director, MD, PhD, Professor, Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States. jidong@utmb.edu |
| Key Words |
Colorectal cancer; KRAS mutation; NRAS mutation; BRAF mutation; Pathological stages, Molecular biomarker; Pyrosequencing |
| Core Tip |
In colorectal cancer, the kirsten rat sarcoma viral oncogene homolog p.Gly12Val and p.Gly13Asp mutations were linked to advanced tumor stage, while the kirsten rat sarcoma viral oncogene homolog p.Gly12Asp and p.Gly12Val mutations showed a positive association with distant metastasis. The v-raf murine sarcoma viral oncogene homolog B1 p.Val600Glu mutation was associated with lymph node metastasis. This study provides evidence to support the prognostic and risk stratification potential of these mutations. Further studies are needed to validate these findings and explore their clinical implications for patients with colorectal cancer. |
| Publish Date |
2025-09-19 09:29 |
| Citation |
<p>Abdelgadir O, Kuo YF, Khan MF, Okorodudu AO, Cheng YWO, Dong J. Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations. <i>World J Gastrointest Pathophysiol</i> 2025; 16(3): 107954</p> |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i3/107954.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i3.107954 |
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