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7/14/2025 12:57:39 PM | Browse: 19 | Download: 27
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Received |
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2025-04-11 08:17 |
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Peer-Review Started |
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2025-04-11 08:17 |
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To Make the First Decision |
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Return for Revision |
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2025-04-25 11:19 |
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Revised |
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2025-05-08 08:54 |
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Second Decision |
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2025-06-19 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-19 06:20 |
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Articles in Press |
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2025-06-19 06:20 |
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Publication Fee Transferred |
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2025-05-09 06:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-02 02:28 |
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Publish the Manuscript Online |
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2025-07-14 12:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Jing Lin, Er-Jiang Tang, Bin Sun, Ai-Li Wang, Ying Chen, Lei Chen, Yi-Yang Xue, A-Jian Li and Chun-Ying Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Yangpu District Science and Technology Commission |
No. YPQ202303 |
| Shanghai Municipal Health Commission Clinical Research Special Project |
No. 202240122 |
| Shanghai Medical Innovation Research Special Project |
No. 22Y11908600 |
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| Corresponding Author |
Chun-Ying Liu, Associate Professor, PhD, National Center for Liver Cancer, Naval Medical University, No. 366 Qianjv Road, Shanghai 201805, China. cyliu@sibcb.ac.cn |
| Key Words |
SAC3 domain containing 1; Metabolic reprogramming; Glycolysis; Adenosine triphosphate production; β-Catenin/c-Myc axis; Hepatocellular carcinoma |
| Core Tip |
The study revealed that the expression of SAC3 domain containing 1 (SAC3D1) was elevated in hepatocellular carcinoma and closely related to a poor prognosis. SAC3D1 facilitated the proliferation and migration of hepatocellular carcinoma cells in vitro and in vivo. The increase of SAC3D1 Leads to more β-Catenin accumulating in the nucleus, facilitating the expression of c-Myc, one of the upstream regulatory factors of glycolysis. The iCRT3, an antagonist of β-Catenin, could counteract the increase of c-Myc induced by SAC3D1, while also downregulating the expression of glycolysis-related proteins. In conclusion, SAC3D1 augmented glycolysis and adenosine triphosphate generation via β-Catenin/c-Myc axis. |
| Publish Date |
2025-07-14 12:56 |
| Citation |
<p>Lin XJ, Tang EJ, Sun B, Wang AL, Chen Y, Chen L, Xue YY, Li AJ, Liu CY. SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2025; 17(7): 107971</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/107971.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.107971 |
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