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9/19/2025 9:49:46 AM | Browse: 74 | Download: 70
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Received |
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2025-04-08 14:49 |
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Peer-Review Started |
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2025-04-08 14:49 |
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To Make the First Decision |
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2025-04-16 15:06 |
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2025-04-18 14:44 |
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Second Decision |
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2025-06-11 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-11 09:26 |
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Articles in Press |
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2025-06-11 09:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-07 15:47 |
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Publish the Manuscript Online |
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2025-09-19 09:29 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Dynamics of tissue and fecal microbiota in active Crohn’s disease and their ability to predict disease state
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amit K Dutta, Dilip Abraham, Ira Praharaj, Blossom Benny, Karthikeyan Govindan, Zayina Zondervenni and AJ Joseph |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Engineering Research Board |
No. EMR/2016/007033 |
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| Corresponding Author |
Amit K Dutta, Academic Fellow, Professor, Department of Gastroenterology, Christian Medical College, Ida Scudder Road, Vellore 632004, Tamil Nādu, India. akdutta1995@gmail.com |
| Key Words |
Fecal microbiota; Mucosal microbiota; Crohn’s disease; Dysbiosis; Biomarker; Functional difference |
| Core Tip |
Gut microbiota is emerging as a key player in the pathogenesis of Crohn’s disease (CD). The mucosal gut microbiota differs in structure and function compared to fecal microbiota, yet most studies have focused on fecal microbiota alone. We evaluated both mucosal and fecal microbiota in adults with active CD and compared this with the healthy controls. Our results show striking differences in bacterial structural and functional characteristics between mucosal and fecal samples in Crohn's disease. Additionally, the mucosal microbiota proved to be a good predictor of disease state and can serve as a novel potential biomarker for diagnosis of CD. |
| Publish Date |
2025-09-19 09:29 |
| Citation |
<p>Dutta AK, Abraham D, Praharaj I, Benny B, Govindan K, Zondervenni Z, Joseph A. Dynamics of tissue and fecal microbiota in active Crohn’s disease and their ability to predict disease state. <i>World J Gastrointest Pathophysiol</i> 2025; 16(3): 108058</p> |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i3/108058.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i3.108058 |
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