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7/16/2025 8:09:50 AM | Browse: 0 | Download: 0
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Received |
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2025-04-07 09:58 |
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Peer-Review Started |
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2025-04-07 09:58 |
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To Make the First Decision |
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Return for Revision |
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2025-04-16 10:50 |
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Revised |
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2025-04-29 14:09 |
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Second Decision |
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2025-06-13 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-13 08:26 |
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Articles in Press |
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2025-06-13 08:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-08 00:45 |
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Publish the Manuscript Online |
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2025-07-16 07:01 |
| ISSN |
2218-6220 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Minireviews |
| Article Title |
Epigenetic clocks of female reproductive system aging: Current application and future prospects
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Lin, Yang-Yi Chen, Shi-Jie Wang, Yang Zhang, Hai-Sheng Huang and Xiu-Quan Zhang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xiu-Quan Zhang, MD, PhD, Professor, Department of Obstetrics and Gynecology, Research Laboratory of Reproductive Genetics, Southern Medical University Shunde Hospital, No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan 528308, Guangdong Province, China. xiuquan.zhang@hsc.utah.edu |
| Key Words |
Uterine aging; Ovarian aging; Methylation; Leukocyte; Granulosa cell; Epigenetic clock; Endometrium |
| Core Tip |
The aim of this minireview is to examine the application of epigenetic clocks in evaluating the functional status of the female reproductive system. Through the assessment of DNA methylation patterns, epigenetic clocks offer a means of estimating biological age and identifying age-related changes in reproductive tissues. Models derived from blood and reproductive-specific tissues demonstrate potential utility in assessing female reproductive health, particularly in quantifying and predicting the biological age of the reproductive system. Epigenetic clocks developed using endometrial tissue, follicular fluid, leukocytes, and granulosa cells exhibit varying capacities for predicting reproductive aging in females. |
| Publish Date |
2025-07-16 07:01 |
| Citation |
<p>Lin J, Chen YY, Wang SJ, Zhang Y, Huang HS, Zhang XQ. Epigenetic clocks of female reproductive system aging: Current application and future prospects. <i>World J Obstet Gynecol</i> 2025; 14(2): 108149</p> |
| URL |
https://www.wjgnet.com/2218-6220/full/v14/i2/108149.htm |
| DOI |
https://dx.doi.org/10.5317/wjog.v14.i2.108149 |
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