Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108215
Country	China

Received	2025-04-08 16:25
Peer-Review Started	2025-04-08 16:25
To Make the First Decision
Return for Revision	2025-04-11 09:36
Revised	2025-04-12 12:32
Second Decision	2025-04-24 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-24 07:47
Articles in Press	2025-04-24 07:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-30 07:49
Publish the Manuscript Online	2025-09-24 09:01

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Hong-Da Qu, Xue Gao, Ping Xiao and Yan Jiao
Funding Agency and Grant Number
Corresponding Author	Yan Jiao, PhD, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Key Words	Microsatellite instability; Colorectal cancer; Nutritional status; Systemic inflammation; Immunotherapy; Gut microbiome
Core Tip	Microsatellite instability-high (MSI-H) colorectal cancer (CRC) represents a biologically distinct subtype characterized not only by its genetic and immunological features but also by unique systemic alterations. Patients with MSI-H CRC often present with heightened systemic inflammation, as evidenced by elevated neutrophil-to-lymphocyte ratio, and impaired nutritional status, including lower body mass index, serum albumin, and altered lipid metabolism. These immunonutritional profiles have direct implications for prognosis, treatment tolerance, and response to immunotherapy. Recognizing the impact of MSI on host systemic status supports a more integrated, personalized approach to patient care, emphasizing the value of nutritional support, anti-inflammatory strategies, and microbiome modulation as potential adjuncts to immunotherapy and conventional treatment.
Publish Date	2025-09-24 09:01
Citation	<p>Qu HD, Gao X, Xiao P, Jiao Y. Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer. <i>World J Gastrointest Surg</i> 2025; 17(9): 108215</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i9/108215.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i9.108215

Full Article (PDF)	WJGS-17-108215-with-cover.pdf
Manuscript File	108215_Auto_Edited_070915.docx
Answering Reviewers	108215-answering-reviewers.pdf
Audio Core Tip	108215-audio.mp3
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Non-Native Speakers of English Editing Certificate	108215-non-native-speakers.pdf
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Scientific Editor Work List	108215-scientific-editor-work-list.pdf
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