Publication Name	World Journal of Gastroenterology
Manuscript ID	108297
Country	Slovenia

Received	2025-04-10 07:06
Peer-Review Started	2025-04-10 07:07
To Make the First Decision
Return for Revision	2025-05-10 18:56
Revised	2025-05-18 10:00
Second Decision	2025-07-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 06:18
Articles in Press	2025-07-02 06:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-22 03:35
Publish the Manuscript Online	2025-07-24 07:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gastrointestinal tract, its pathophysiology and in-vitro models: A “quick” reference guide to translational studies
Manuscript Source	Invited Manuscript
All Author List	Kristijan Skok, Boštjan Vihar, Uroš Maver, Lidija Gradišnik, Konstantin Bräutigam, Martin Trapecar and Pavel Skok
Funding Agency and Grant Number
Corresponding Author	Pavel Skok, Department of Gastroenterology, University Clinical Center Maribor, Ljubljanska 5, Maribor 2000, Slovenia. pavel.skok@guest.arnes.si
Key Words	Cell line; Tumour cell line; In vitro techniques; Gastrointestinal tract; Organoids; Organ-on-chip
Core Tip	This review highlights the need for advanced in-vitro models to better replicate the gastrointestinal (GI) tract’s complexity for translational research. It compares the evolution from conventional 2-dimensional cultures toward 3-dimensional and microfluidic systems. Key advancements include the use of patient-derived cells, engineered microenvironments, and bioprinting techniques like micro-extrusion and laser-assisted printing. These technologies enable modeling of essential processes such as peristalsis, molecular transport, and liver coupling. By enhancing physiological relevance, these models support personalized medicine and improve the predictive power of preclinical GI research.
Publish Date	2025-07-24 07:47
Citation	<p>Skok K, Vihar B, Maver U, Gradišnik L, Bräutigam K, Trapecar M, Skok P. Gastrointestinal tract, its pathophysiology and in-vitro models: A “quick” reference guide to translational studies. <i>World J Gastroenterol</i> 2025; 31(28): 108297</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i28/108297.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i28.108297

Full Article (PDF)	WJG-31-108297-with-cover.pdf
Manuscript File	108297_Auto_Edited_014537.docx
Answering Reviewers	108297-answering-reviewers.pdf
Audio Core Tip	108297-audio.m4a
Conflict-of-Interest Disclosure Form	108297-conflict-of-interest-statement.pdf
Copyright License Agreement	108297-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108297-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	108297-non-native-speakers.pdf
Peer-review Report	108297-peer-reviews.pdf
Scientific Misconduct Check	108297-scientific-misconduct-check.png
Scientific Editor Work List	108297-scientific-editor-work-list.pdf
CrossCheck Report	108297-crosscheck-report.pdf